(Q30422919)

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20 February 2020

title

A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

16

1 reference

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20 February 2020

author name string

Cynthia X Ma

1

1 reference

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20 February 2020

Matthew J C Ellis

2

1 reference

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20 February 2020

Gina R Petroni

3

1 reference

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20 February 2020

Zhanfang Guo

4

1 reference

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20 February 2020

Shi-Rong Cai

5

1 reference

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20 February 2020

Christine E Ryan

6

1 reference

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20 February 2020

A Craig Lockhart

7

1 reference

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20 February 2020

Michael J Naughton

8

1 reference

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20 February 2020

Timothy J Pluard

9

1 reference

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20 February 2020

Christiana M Brenin

10

1 reference

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20 February 2020

Joel Picus

11

1 reference

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20 February 2020

Allison N Creekmore

12

1 reference

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20 February 2020

Tibu Mwandoro

13

1 reference

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20 February 2020

Erin R Yarde

14

1 reference

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20 February 2020

Jerry Reed

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Philip S Bernard

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Mark Watson

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Laurence A Doyle

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Janet Dancey

20

1 reference

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20 February 2020

Helen Piwnica-Worms

21

1 reference

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20 February 2020

Paula M Fracasso

22

1 reference

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20 February 2020

language of work or name

English

0 references

publication date

15 December 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json

Breast Cancer Research and Treatment

20 February 2020

published in

1 reference

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20 February 2020

volume

137

1 reference

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20 February 2020

issue

2

1 reference

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20 February 2020

page(s)

483-492

1 reference

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Creative Commons Attribution-NonCommercial 2.5 Generic

20 February 2020

copyright license

start time

15 December 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer

20 June 2018

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Targeting triple-negative breast cancer: optimising therapeutic outcomes

20 June 2018

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The clonal and mutational evolution spectrum of primary triple-negative breast cancers

20 June 2018

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Dissecting the heterogeneity of triple-negative breast cancer

20 June 2018

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Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.

20 June 2018

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20 June 2018

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Molecular heterogeneity of triple-negative breast cancer and its clinical implications

20 June 2018

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p53 status identifies two subgroups of triple-negative breast cancers with distinct biological features

20 June 2018

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

20 June 2018

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Triple-Negative Breast Cancer

20 June 2018

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Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

20 June 2018

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A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies

20 June 2018

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New insights into checkpoint kinase 1 in the DNA damage response signaling network

20 June 2018

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Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer

20 June 2018

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The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

20 June 2018

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Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design

20 June 2018

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DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress

20 June 2018

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Supervised risk predictor of breast cancer based on intrinsic subtypes

20 June 2018

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Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

20 June 2018

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Triple-negative breast cancer: clinical features and patterns of recurrence

20 June 2018

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The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas

20 June 2018

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Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors

20 June 2018

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Targeting checkpoint kinase 1 in cancer therapeutics

20 June 2018

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Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study

20 June 2018

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Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

20 June 2018

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PDK1, the master regulator of AGC kinase signal transduction

20 June 2018

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Cell cycle checkpoints and their impact on anticancer therapeutic strategies

20 June 2018

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Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

20 June 2018

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

20 June 2018

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

20 June 2018

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Protein kinases: getting NEKed for S6K activation

20 June 2018

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P53 status plays no role in radiosensitizing effects of SN-38, a camptothecin derivative

20 June 2018

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The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

20 June 2018

1 reference

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

20 June 2018

1 reference

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

20 June 2018

1 reference

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Participation of p53 protein in the cellular response to DNA damage

20 June 2018

1 reference

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Randomized phase II study of two irinotecan schedules for patients with metastatic breast cancer refractory to an anthracycline, a taxane, or both

20 June 2018

1 reference

Crossref

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Clinical effect of irinotecan in advanced and metastatic breast cancer patients previously treated with doxorubicin- and docetaxel-containing regimens

21 January 2018

1 reference

Crossref

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p53 as a specific prognostic factor in triple-negative breast cancer

21 January 2018

1 reference

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Modulation of cell cycle progression in human tumors: a pharmacokinetic and tumor molecular pharmacodynamic study of cisplatin plus the Chk1 inhibitor UCN-01 (NSC 638850)

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23242585

12 December 2020

Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest

1 reference

https://pubmed.ncbi.nlm.nih.gov/23242585

12 December 2020

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23242585

12 December 2020

UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23242585

12 December 2020

UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23242585

12 December 2020

Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23242585

12 December 2020

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23242585

12 December 2020

10.1007/S10549-012-2378-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

1029818814

0 references

Fatcat ID

release_ptw75o43ondmjlwhbuuwg6f4fe

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ptw75o43ondmjlwhbuuwg6f4fe

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

23242585

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242585%20AND%20SRC:MED&resulttype=core&format=json