(Q30396736)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996294%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996294%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

13

1 reference

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8 March 2020

Andreas Linkermann

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996294%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Astrid Fauster

1

1 reference

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8 March 2020

Manuele Rebsamen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996294%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Kilian Huber

3

1 reference

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8 March 2020

Johannes W Bigenzahn

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996294%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Jacques Colinge

11

1 reference

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8 March 2020

Giulio Superti-Furga

16

1 reference

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8 March 2020

author name string

A Stukalov

5

1 reference

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8 March 2020

C-H Lardeau

6

1 reference

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8 March 2020

S Scorzoni

7

1 reference

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8 March 2020

M Bruckner

8

1 reference

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8 March 2020

M Gridling

9

1 reference

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8 March 2020

K Parapatics

10

1 reference

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8 March 2020

K L Bennett

12

1 reference

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8 March 2020

S Krautwald

14

1 reference

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8 March 2020

publication date

21 May 2015

1 reference

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8 March 2020

published in

Cell Death and Disease

1 reference

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8 March 2020

volume

6

1 reference

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8 March 2020

page(s)

e1767

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Creative Commons Attribution 4.0 International

8 March 2020

copyright license

start time

1 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Necroptosis and its role in inflammation

1 reference

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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

28 July 2018

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Programmed necrosis in the cross talk of cell death and inflammation

28 July 2018

1 reference

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RIP3 induces apoptosis independent of pronecrotic kinase activity

28 July 2018

1 reference

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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

28 July 2018

1 reference

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RIP kinases: key decision makers in cell death and innate immunity

28 July 2018

1 reference

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TAK1 control of cell death

28 July 2018

1 reference

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The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

28 July 2018

1 reference

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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

28 July 2018

1 reference

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RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

28 July 2018

1 reference

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MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

28 July 2018

1 reference

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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

28 July 2018

1 reference

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Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

28 July 2018

1 reference

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TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

28 July 2018

1 reference

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28 July 2018

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

28 July 2018

1 reference

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

28 July 2018

1 reference

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A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias

28 July 2018

1 reference

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Necroptosis in immunity and ischemia-reperfusion injury

28 July 2018

1 reference

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Control of life-or-death decisions by RIP1 kinase

28 July 2018

1 reference

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Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration.

28 July 2018

1 reference

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Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

28 July 2018

1 reference

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Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

28 July 2018

1 reference

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Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

28 July 2018

1 reference

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Ponatinib in refractory Philadelphia chromosome-positive leukemias

28 July 2018

1 reference

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Pushing the limits of targeted therapy in chronic myeloid leukaemia.

28 July 2018

1 reference

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The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

28 July 2018

1 reference

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Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

28 July 2018

1 reference

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

28 July 2018

1 reference

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Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways

28 July 2018

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Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

28 July 2018

1 reference

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Programmed cell death in animal development and disease

28 July 2018

1 reference

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Comprehensive analysis of kinase inhibitor selectivity

28 July 2018

1 reference

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Programmed necrosis from molecules to health and disease

28 July 2018

1 reference

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Modeling contaminants in AP-MS/MS experiments

28 July 2018

1 reference

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Virus inhibition of RIP3-dependent necrosis

28 July 2018

1 reference

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Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma

28 July 2018

1 reference

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Target profiling of small molecules by chemical proteomics

28 July 2018

1 reference

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DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

28 July 2018

1 reference

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

28 July 2018

1 reference

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

28 July 2018

1 reference

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

28 July 2018

1 reference

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Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

28 July 2018

1 reference

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Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor

28 July 2018

1 reference

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Identification of RIP1 kinase as a specific cellular target of necrostatins

28 July 2018

1 reference

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Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib

28 July 2018

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

28 July 2018

1 reference

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The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

28 July 2018

1 reference

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

28 July 2018

1 reference

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Crosstalk between apoptosis, necrosis and autophagy

28 July 2018

1 reference

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Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

21 January 2018

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

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Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

21 January 2018

1 reference

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DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

21 January 2018

1 reference

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Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

21 January 2018

1 reference

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A plug release mechanism for membrane permeation by MLKL.

21 January 2018

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A role of RIP3-mediated macrophage necrosis in atherosclerosis development.

21 January 2018

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Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo.

21 January 2018

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RIPK3-mediated necroptosis promotes donor kidney inflammatory injury and reduces allograft survival.

21 January 2018

1 reference

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FADD deficiency sensitises Jurkat T cells to TNF-alpha-dependent necrosis during activation-induced cell death

21 January 2018

1 reference

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AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

21 January 2018

1 reference

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Structure-activity relationship study of novel necroptosis inhibitors

21 January 2018

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Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

21 January 2018

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Phase I trial of pazopanib in patients with advanced cancer.

21 January 2018

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Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial

21 January 2018

1 reference

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An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

21 January 2018

1 reference

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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

21 January 2018

1 reference

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FADD is required for multiple signaling events downstream of the receptor Fas.

26 November 2018

1 reference

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Pazopanib in renal cell carcinoma

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25996294

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulated cell death and inflammation: an auto-amplification loop causes organ failure

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25996294

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2015.130

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996294%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996294%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

25996294

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996294%20AND%20SRC:MED&resulttype=core&format=json