Wikidata

(Q29819808)

English

Cubitus interruptus Dmel_CG2125

Protein found in Drosophila melanogaster

  • cubitus interruptus
  • cubitus-interruptus
  • cubitis interruptus
  • cubitus
  • cell
  • CG2125 gene product from transcript CG2125-RB
  • CG2125-PC
  • ci-PB
  • CG2125-PA
  • ci
  • CG2125-PB
  • cubitus-interruptus-Dominant
  • cubitus interuptus
  • ci-PC
  • ci-PA
In more languages
default values for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
16 references
retrieved
8 April 2019
stated in
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.
GOA
curator
UniProt
UniProt protein ID
P19538
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
A protein interaction map of Drosophila melanogaster
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
retrieved
8 April 2019
stated in
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
NAS
10 references
retrieved
8 April 2019
stated in
Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila
GOA
curator
UniProt
UniProt protein ID
P19538
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P19538
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IEA
retrieved
8 April 2019
stated in
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Sequential phosphorylation of smoothened transduces graded hedgehog signaling.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
cytosol
determination method
IDA
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
TAS
retrieved
8 April 2019
stated in
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
The role of segment polarity genes during early oogenesis in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
biological process
smoothened signaling pathway
determination method
IEP
IMP
NAS
TAS
8 references
retrieved
10 September 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538
determination method
TAS
retrieved
10 September 2018
stated in
Regulation of Hedgehog signaling: a complex story
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538
determination method
TAS
retrieved
10 September 2018
stated in
Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538
determination method
TAS
retrieved
10 September 2018
stated in
Selector and signalling molecules cooperate in organ patterning
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538
determination method
NAS
retrieved
10 September 2018
stated in
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538
determination method
IMP
retrieved
10 September 2018
stated in
Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538
determination method
IMP
retrieved
10 September 2018
stated in
An absolute requirement for Cubitus interruptus in Hedgehog signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538
determination method
IMP
retrieved
10 September 2018
stated in
The role of segment polarity genes during early oogenesis in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538
determination method
IEP
smoothened signaling pathway
determination method
IDA
IEP
IGI
IMP
TAS
9 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
TAS
retrieved
8 April 2019
stated in
An absolute requirement for Cubitus interruptus in Hedgehog signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IMP
retrieved
8 April 2019
stated in
Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IMP
retrieved
8 April 2019
stated in
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IGI
retrieved
8 April 2019
stated in
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IGI
retrieved
8 April 2019
stated in
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IGI
retrieved
8 April 2019
stated in
The role of segment polarity genes during early oogenesis in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IEP
retrieved
8 April 2019
stated in
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA
retrieved
8 April 2019
stated in
Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538
determination method
IDA

Identifiers

 
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