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English
Regulation of angiogenesis by hypoxia: role of the HIF system
scientific article (publication date: June 2003)
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Europe PubMed Central
title
Regulation of angiogenesis by hypoxia: role of the HIF system
(English)
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stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
main subject
hypoxia
0 references
angiogenesis
1 reference
based on heuristic
inferred from title
author
Peter J. Ratcliffe
object named as
Ratcliffe PJ
series ordinal
2
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author name string
Pugh CW
series ordinal
1
1 reference
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PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
language of work or name
English
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
publication date
June 2003
1 reference
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PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
published in
Nature Medicine
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
volume
9
1 reference
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PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
issue
6
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
page(s)
677-84
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
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A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
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Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia
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Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia.
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Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide
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Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.
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Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia
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Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
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Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia
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Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation
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Hypoxia promotes fibrogenesis in human renal fibroblasts
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Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells
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Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes
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Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells
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Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
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Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors.
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Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
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Macrovascular and microvascular endothelium during long-term hypoxia: alterations in cell growth, monolayer permeability, and cell surface coagulant properties
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Distinct effect of hypoxia on endothelial cell proliferation and cycling
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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.
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https://api.crossref.org/works/10.1038%2FNM0603-677
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7 January 2021
based on heuristic
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Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
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7 January 2021
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Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia
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Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.
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based on heuristic
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The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
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Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
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Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development
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HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin
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Crossref
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7 January 2021
based on heuristic
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HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration
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Crossref
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https://api.crossref.org/works/10.1038%2FNM0603-677
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7 January 2021
based on heuristic
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Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Early expression of angiogenesis factors in acute myocardial ischemia and infarction
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FNM0603-677
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7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
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7 January 2021
based on heuristic
inferred from DOI database lookup
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Impaired oxygen-dependent reduction of HIF-1alpha and -2alpha proteins in pre-eclamptic placentae
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Crossref
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7 January 2021
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Expression of hypoxia-inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint
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7 January 2021
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Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha
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7 January 2021
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Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor
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7 January 2021
based on heuristic
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Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat.
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PR39, a peptide regulator of angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
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inferred from DOI database lookup
Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the HIF pathway in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
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inferred from DOI database lookup
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of tumor growth through disruption of hypoxia-inducible transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular basis of the VHL hereditary cancer syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour suppression by the human von Hippel-Lindau gene product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chasing the cancer demon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM0603-677
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism
1 reference
stated in
COCI
retrieved
12 October 2022
reference URL
https://opencitations.net/index/coci/api/v1/references/10.1038/NM0603-677
Identifiers
DOI
10.1038/NM0603-677
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
786238
Dimensions Publication ID
1020460331
0 references
OpenCitations bibliographic resource ID
786238
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
786238
PubMed publication ID
12778166
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12778166
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
786238
ResearchGate publication ID
10733340
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