(Q29616564)

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

scientific article (publication date: June 2000)

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10818140

30 April 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

author name string

G Q Yu

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

M Mallory

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

E M Rockenstein

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

G Tatsuno

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

K Hu

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

D Kholodenko

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

K Johnson-Wood

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

L McConlogue

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

language of work or name

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10818140

30 April 2017

publication date

1 June 2000

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10818140

30 April 2017

Journal of Neuroscience

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10818140

30 April 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

20

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10818140

30 April 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

11

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10818140

30 April 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

4050-4058

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neocortical synapse density and Braak stage in the Lewy body variant of Alzheimer disease: a comparison with classic Alzheimer disease and normal aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic and neuritic alterations during the progression of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of neuronal changes in the course of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional synaptic pathology in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measuring memory in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlations of synaptic and pathological markers with cognition of the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New clues to Alzheimer's disease: unraveling the roles of amyloid and tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that Aβ42 is the real culprit in alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spectrum of human immunodeficiency virus-associated neocortical damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A detergent-insoluble membrane compartment contains A beta in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mean A beta load in the hippocampus correlates with duration and severity of dementia in subgroups of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular APP processing and A beta production in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 'amyloid cascade hypothesis' of AD: decoy or real McCoy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron loss in APP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of amyloid β protein from its precursor is sequence specific

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: a review of the disease, its epidemiology and economic impact

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple dot-immunobinding assay for quantification of synaptophysin-like immunoreactivity in human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta associated neuropil changes: correlation with neuronal loss and dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation and regulation of beta-amyloid peptide variants by neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of beta-amyloid protein deposits in brains of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/10818140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.20-11-04050.2000

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

PubMed publication ID

3 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10818140

30 April 2017

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772621&resulttype=core&format=json

12 May 2020

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