(Q29346869)

11 April 2017

title

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks (English)

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11 April 2017

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MRX complex nuclease subunit YMR224C

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SsDNA endodeoxyribonuclease SAE2 YGL175C

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MRX complex DNA-binding subunit YNL250W

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author name string

Elda Cannavo

series ordinal

1

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11 April 2017

Petr Cejka

series ordinal

2

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11 April 2017

language of work or name

English

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publication date

17 September 2014

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11 April 2017

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11 April 2017

volume

514

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11 April 2017

issue

7520

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11 April 2017

page(s)

122-125

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Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

11 April 2017

cites work

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Yeast Xrs2 Binds DNA and Helps Target Rad50 and Mre11 to DNA Ends

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

CDK targets Sae2 to control DNA-end resection and homologous recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Functional interactions between Sae2 and the Mre11 complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231868

12 December 2020