(Q28640044)

3 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

title

Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia (English)

2 references

3 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

main subject

transmembrane protein

0 references

author name string

M K Webster

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

D J Donoghue

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

language of work or name

English

0 references

publication date

1 February 1996

2 references

3 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

2 references

3 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

volume

15

2 references

3 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

issue

3

2 references

3 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

page(s)

520-527

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

Structural and functional diversity in the FGF receptor multigene family

15 October 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

High-efficiency transformation of mammalian cells by plasmid DNA

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Signal transduction by receptors with tyrosine kinase activity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

The v-sis protein retains biological activity as a type II membrane protein when anchored by various signal-anchor domains, including the hydrophobic domain of the bovine papilloma virus E5 oncoprotein

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Cellular transformation by a transmembrane peptide: structural requirements for the bovine papillomavirus E5 oncoprotein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Specific short transmembrane sequences can inhibit transformation by the mutant neu growth factor receptor in vitro and in vivo.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Achondroplasia is defined by recurrent G380R mutations of FGFR3

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Signalling by receptor tyrosine kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

SHC and GRB-2 Are Constitutively Activated by an Epidermal Growth Factor Receptor with a Point Mutation in the Transmembrane Domain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Birth prevalence rates of skeletal dysplasias.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Congenital generalised bone dysplasias: a clinical, radiological, and epidemiological survey

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

A sequence motif in the transmembrane region of growth factor receptors with tyrosine kinase activity mediates dimerization

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Enhancement of tyrosine kinase activity of the Drosophila epidermal growth factor receptor homolog by alterations of the transmembrane domain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

p185HER2 signal transduction in breast cancer cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Structural and biosynthetic characterization of the fibroblast growth factor receptor 3 (FGFR-3) protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Molecular definition of the smallest region of deletion overlap in the Wolf-Hirschhorn syndrome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

A subdomain in the transmembrane domain is necessary for p185neu* activation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Intracellular retention of membrane-anchored v-sis protein abrogates autocrine signal transduction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Achondroplasia and hypochondroplasia. Comments on frequency, mutation rate, and radiological features in skull and spine

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449970

Localization of the achondroplasia gene to the distal 2.5 Mb of human chromosome 4p

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/8599935

12 December 2020

Skeletal growth in achondroplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8599935

12 December 2020

Histochemistry and ultrastructure of the growth plate in achondroplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8599935

12 December 2020

Reduction of basic fibroblasts growth factor receptor is coupled with terminal differentiation of chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8599935

12 December 2020

Neu receptor dimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/8599935

12 December 2020

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8599935

12 December 2020

10.1002/J.1460-2075.1996.TB00384.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8599935%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

2 references

3 February 2017