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Recognition of DNA by designed ligands at subnanomolar concentrations

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Recognition of DNA by designed ligands at subnanomolar concentrations (English)

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J W Trauger

1

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E E Baird

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2

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P B Dervan

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3

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language of work or name

English

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publication date

8 August 1996

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published in

Nature

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volume

382

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issue

6591

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page(s)

559-61

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cites work

Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin

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Binding affinities of synthetic peptides, pyridine-2-carboxamidonetropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA.

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Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.

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Structural and dynamic characterization of the heterodimeric and homodimeric complexes of distamycin and 1-methylimidazole-2-carboxamide-netropsin bound to the minor groove of DNA.

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Design of a G.C-specific DNA minor groove-binding peptide.

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Cyclic polyamides for recognition in the minor groove of DNA

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DNAase footprinting a simple method for the detection of protein-DNA binding specificity

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DNA structural variations produced by actinomycin and distamycin as revealed by DNAase I footprinting.

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Quantitative DNase footprint titration: a method for studying protein-DNA interactions

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Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding

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Toward rules relating zinc finger protein sequences and DNA binding site preferences

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Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins

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In vitro selection of zinc fingers with altered DNA-binding specificity

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Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

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Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage

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Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions

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Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence

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57 Sequencing end-labeled DNA with base-specific chemical cleavages

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Adenine specific DNA chemical sequencing reaction

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retrieved

7 January 2021

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(Q28284127)

Recognition of DNA by designed ligands at subnanomolar concentrations

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