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Bcl-2 promotes regeneration of severed axons in mammalian CNS

21 April 2017

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The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS

21 April 2017

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Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

21 April 2017

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GSK-3: tricks of the trade for a multi-tasking kinase

21 April 2017

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Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression

21 April 2017

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Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins

21 April 2017

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Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling

21 April 2017

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Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators

21 April 2017

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A molecular mechanism for the effect of lithium on development

21 April 2017

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A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase

21 April 2017

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Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis

21 April 2017

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Circadian genes, rhythms and the biology of mood disorders

21 April 2017

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Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

21 April 2017

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Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain

21 April 2017

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A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control

21 April 2017

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Computerised tomographic scan changes in manic-depressive illness

21 April 2017

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 April 2017

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SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior

21 April 2017

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Untreated Depression and Hippocampal Volume Loss

21 April 2017

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Hippocampal atrophy in recurrent major depression

21 April 2017

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Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate

21 April 2017

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Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans

21 April 2017

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Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study

21 April 2017

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NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

21 April 2017

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The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers

21 April 2017

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AMPA receptor trafficking and synaptic plasticity

21 April 2017

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Wnt signalling in stem cells and cancer

21 April 2017

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Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

21 April 2017

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21 April 2017

The renaissance of GSK3

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The glamour and gloom of glycogen synthase kinase-3

21 April 2017

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Wnt signalling regulates adult hippocampal neurogenesis

21 April 2017

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

21 April 2017

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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

21 April 2017

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Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants.

21 April 2017

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The Bcl-2 protein family: arbiters of cell survival

21 January 2018

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Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics

21 January 2018

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Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study

21 January 2018

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Unipolar-bipolar dichotomy of mood disorders is supported by noradrenergic brainstem system morphology

21 January 2018

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The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review

21 January 2018

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Greater cortical gray matter density in lithium-treated patients with bipolar disorder

21 January 2018

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Reductions in cholesterol and synaptic markers in association cortex in mood disorders.

21 January 2018

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

21 January 2018

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GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder

21 January 2018

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The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects

21 January 2018

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Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain

21 January 2018

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Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging

21 January 2018

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Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

21 January 2018

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Low glial numbers in the amygdala in major depressive disorder

21 January 2018

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Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects

21 January 2018

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Wnts as retrograde signals for axon and growth cone differentiation.

21 January 2018

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DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia

21 January 2018

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Magnesium valproate attenuates hyperactivity induced by dexamphetamine-chlordiazepoxide mixture in rodents

21 January 2018

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Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targets

21 January 2018

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Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy

21 January 2018

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Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

21 January 2018

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Decreased N-acetylaspartate in children with familial bipolar disorder

21 January 2018

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Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells.

21 January 2018

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The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers

21 January 2018

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Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases?

21 January 2018

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In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked?

21 January 2018

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GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

21 January 2018

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The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia.

21 January 2018

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Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder.

21 January 2018

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Lack of lithium-like behavioral and molecular effects in IMPA2 knockout mice

21 January 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium

21 January 2018

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Lower Concentration of HippocampalN-Acetylaspartate in Familial Bipolar I Disorder

21 January 2018

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Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling

21 January 2018

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Lithium stimulates glutamate "release" and inositol 1,4,5-trisphosphate accumulation via activation of the N-methyl-D-aspartate receptor in monkey and mouse cerebral cortex slices

21 January 2018

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Lithium- and valproate-induced alterations in circadian locomotor behavior in Drosophila

21 January 2018

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Neuroimaging studies of mood disorders

21 January 2018

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Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

21 January 2018

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Subgenual prefrontal cortex abnormalities in mood disorders

21 January 2018

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Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression

21 January 2018

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Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action

21 January 2018

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The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders

21 January 2018

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A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment

21 January 2018

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An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.

21 January 2018

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Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression.

21 January 2018

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Sodium valproate decreases exploratory behaviour in mice: development of tolerance and cross-tolerance with chlordiazepoxide

21 January 2018

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

21 January 2018

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The Maudsley bipolar disorder project. A survey of psychotropic prescribing patterns in bipolar I disorder

21 January 2018

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Magnetic resonance imaging studies in early-onset bipolar disorder: a critical review

21 January 2018

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In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3.

21 January 2018

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AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test

21 January 2018

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Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders

21 January 2018

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Lithium and valproic acid: parallels and contrasts in diverse signaling contexts

21 January 2018

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Maintenance efficacy of divalproex in the prevention of bipolar depression

21 January 2018

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Neuroanatomical abnormalities as risk factors for bipolar disorder

21 January 2018

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Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons

21 January 2018

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Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders

21 January 2018

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Reduced intracellular pH in the basal ganglia and whole brain measured by 31P-MRS in bipolar disorder

21 January 2018

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Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis.

21 January 2018

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Lithium stimulates progenitor proliferation in cultured brain neurons.

21 January 2018

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Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia

21 January 2018

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Activation of the Wnt signaling pathway: a molecular mechanism for lithium action

21 January 2018

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Synapsins as regulators of neurotransmitter release

21 January 2018

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Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

21 January 2018

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Growth-associated protein (GAP-43), its mRNA, and protein kinase C (PKC) isoenzymes in brain regions of depressed suicides

21 January 2018

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Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease

21 January 2018

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Initiation and adaptation: a paradigm for understanding psychotropic drug action

21 January 2018

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Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium

21 January 2018

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Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

21 January 2018

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Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium

21 January 2018

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Decreased brain intracellular pH measured by 31P-MRS in bipolar disorder: a confirmation in drug-free patients and correlation with white matter hyperintensity

21 January 2018

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Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder

21 January 2018

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GSK3, a master switch regulating cell-fate specification and tumorigenesis

21 January 2018

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Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth

21 January 2018

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Molecular evidence for mitochondrial dysfunction in bipolar disorder

21 January 2018

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Endophenotypes in bipolar disorder

21 January 2018

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The poor prognosis of childhood-onset bipolar disorder

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Deciphering the pathways of life and death

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Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection

21 January 2018

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Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder.

21 January 2018

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Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival

21 January 2018

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Hippocampal CA1 pyramidal cell size is reduced in bipolar disorder

21 January 2018

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A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation

21 January 2018

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Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

21 January 2018

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White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders

21 January 2018

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Course of illness, hippocampal function, and hippocampal volume in major depression

21 January 2018

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Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?

21 January 2018

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A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock

21 January 2018

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Lithium-Sensitive Production of Inositol Phosphates During Amphibian Embryonic Mesoderm Induction

21 January 2018

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Mitochondrial regulation of neuronal plasticity

21 January 2018

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Bcl-2 gene family in the nervous system

21 January 2018

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Cerebral white matter lesions in bipolar affective disorder: relationship to outcome

21 January 2018

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Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons

21 January 2018

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

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A volumetric magnetic resonance imaging study of monozygotic twins discordant for bipolar disorder

21 January 2018

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Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium

21 January 2018

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Glial reduction in the subgenual prefrontal cortex in mood disorders

21 January 2018

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Glycogen synthase kinase 3beta as a likely target for the action of lithium on circadian clocks

21 January 2018

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Parvalbumin neurons in the entorhinal cortex of subjects diagnosed with bipolar disorder or schizophrenia.

21 January 2018

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Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates.

21 January 2018

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Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder

21 January 2018

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Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena

21 January 2018

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Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania.

21 January 2018

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BCL-2 overexpression attenuates cortical cell loss after traumatic brain injury in transgenic mice

21 January 2018

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Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

21 January 2018

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Cell pathology in bipolar disorder

21 January 2018

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Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder

21 January 2018

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Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model

21 January 2018

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Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

21 January 2018

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Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine

21 January 2018

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Mania-like behavior induced by disruption of CLOCK

21 January 2018

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Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos

21 January 2018

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Divergent roles of GSK3 and CDK5 in APP processing

21 January 2018

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Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

21 January 2018

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Bcl-2 family members in the development and degenerative pathologies of the nervous system

21 January 2018

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Increased gray matter volume in lithium-treated bipolar disorder patients

21 January 2018

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Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients

21 January 2018

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Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder

21 January 2018

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Decreased regional cortical gray matter volume in schizophrenia

21 January 2018

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Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae

21 January 2018

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Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol

21 January 2018

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Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase

21 January 2018

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Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder

21 January 2018

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Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation

21 January 2018

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Neuroimaging in bipolar disorder: what have we learned?

21 January 2018

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Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research

21 January 2018

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Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder

21 January 2018

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Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

21 January 2018

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Risk of Recurrence Following Discontinuation of Lithium Treatment in Bipolar Disorder

21 January 2018

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Lithium and dementia: a preliminary study

21 January 2018

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Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study

21 January 2018

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Immunoreactivity of 43 kDa growth-associated protein is decreased in post mortem hippocampus of bipolar disorder and schizophrenia.

21 January 2018

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Oligodendrocyte dysfunction in schizophrenia and bipolar disorder

21 January 2018

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Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

21 January 2018

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Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium.

21 January 2018

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Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia

21 January 2018

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31P magnetic resonance spectroscopy in the frontal lobe of major depressed patients

21 January 2018

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Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder.

21 January 2018

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Synaptic activity-dependent modulation of mitochondrial gene expression in the rat hippocampus

21 January 2018

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A common mechanism of action for three mood-stabilizing drugs

21 January 2018

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Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder

21 January 2018

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Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death

21 January 2018

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Ca2+ influx–independent synaptic potentiation mediated by mitochondrial Na+-Ca2+ exchanger and protein kinase C

21 January 2018

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Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock

21 January 2018

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GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.

21 January 2018

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The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth

21 January 2018

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An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression

21 January 2018

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Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder

21 January 2018

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Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.

21 January 2018

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Deficits in gray matter volume are present in schizophrenia but not bipolar disorder

21 January 2018

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Does long-term medication with lithium, clozapine or antidepressants prevent or attenuate dementia in bipolar and depressed patients?

21 January 2018

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7 January 2021

Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol

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7 January 2021

Lithium as a prophylactic agents. Its effect against recurrent depressions and manic-depressive psychosis

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7 January 2021

Fragile X: translation in action

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7 January 2021

A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania

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7 January 2021

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7 January 2021

GAP-43 as a marker for structural plasticity in the mature CNS.

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7 January 2021

Volume deficits of subcortical nuclei in mood disorders A postmortem study

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7 January 2021

Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2

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7 January 2021

Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder

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7 January 2021

Enhancement of hippocampal neurogenesis by lithium

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7 January 2021

Mood stabilizers in the prevention of recurrent affective disorders: a meta-analysis

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7 January 2021

Abnormal frontal lobe phosphorous metabolism in bipolar disorder

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7 January 2021

Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs

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7 January 2021

Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded 31P-MRS

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7 January 2021

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

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7 January 2021

The increasing medical burden in bipolar disorder

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7 January 2021

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

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7 January 2021

Cell signaling. The art of the soluble

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7 January 2021

Interaction between BDNF and serotonin: role in mood disorders

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7 January 2021

Neuroplasticity mediated by altered gene expression

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7 January 2021

Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?

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7 January 2021

Lithium-induced increase in human brain grey matter

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7 January 2021

Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder

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7 January 2021

Clinical correlates of lateral ventricular enlargement in bipolar affective disorder

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7 January 2021

Stress, depression, and neuroplasticity: a convergence of mechanisms

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7 January 2021

The neurite retraction induced by lysophosphatidic acid increases Alzheimer's disease-like Tau phosphorylation

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7 January 2021

Potential antidepressant properties of subchronic GABA transaminase inhibitors in the forced swimming test in mice

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7 January 2021

Lithium enhances long‐term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus

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7 January 2021

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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7 January 2021

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.

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7 January 2021

Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment

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7 January 2021