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STAT4: a critical regulator of inflammation in vivo
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scholarly article
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review article
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Europe PubMed Central
title
STAT4: a critical regulator of inflammation in vivo
(English)
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main subject
inflammation
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author
Mark H. Kaplan
object named as
Mark H Kaplan
series ordinal
1
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language of work or name
English
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publication date
2005
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published in
Immunologic Research
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volume
31
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issue
3
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page(s)
231-42
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cites work
Relative importance of STAT4 in murine tuberculosis
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impairment of IL-12-dependent STAT4 nuclear translocation in a patient with recurrent Mycobacterium avium infection
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Susceptibility to Leishmania mexicana infection is due to the inability to produce IL-12 rather than lack of IL-12 responsiveness.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-12 and the regulation of innate resistance and adaptive immunity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Signal transducer and activator of transcription (Stat)-6-dependent, but not Stat4-dependent, immunity is required for the development of autoimmunity in Graves' hyperthyroidism
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Attenuated cardiac allograft vasculopathy in mice with targeted deletion of the transcription factor STAT4
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Jaks and STATs: biological implications
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
IL-12, while beneficial, is not essential for the host response to VSV encephalitis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Infection-Triggered Regulatory Mechanisms Override the Role of STAT 4 in Control of the Immune Response to Influenza Virus Antigens
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Autoimmune diabetes is blocked in Stat4-deficient mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
IL-4 and IL-12 Regulate Proteoglycan-Induced Arthritis Through Stat-Dependent Mechanisms
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A STAT4-dependent Th1 response is required for resistance to the helminth parasite Taenia crassiceps.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Stat3 and Stat4: members of the family of signal transducers and activators of transcription
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Neonatal tolerance in the absence of Stat4- and Stat6- dependent Th cell differentiation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CD4+ T cells regulate surgical and postinfectious adhesion formation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15888914
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1385/IR:31:3:231
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2182456
Dimensions Publication ID
1009563232
0 references
OpenCitations bibliographic resource ID
2182456
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2182456
PubMed publication ID
15888914
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2182456
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