(Q28144965)

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6 November 2019

title

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo (English)

1 reference

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6 November 2019

main subject

protein ubiquitination

1 reference

2

1 reference

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6 November 2019

David P. Lane

7

1 reference

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6 November 2019

author name string

C A Midgley

1

1 reference

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6 November 2019

M K Saville

3

1 reference

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6 November 2019

S Howard

4

1 reference

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6 November 2019

A Sparks

5

1 reference

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6 November 2019

R T Hay

6

1 reference

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6 November 2019

language of work or name

English

0 references

publication date

1 May 2000

1 reference

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6 November 2019

1 reference

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6 November 2019

volume

19

1 reference

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6 November 2019

issue

19

1 reference

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6 November 2019

page(s)

2312-2323

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10822382%20AND%20SRC:MED&resulttype=core&format=json

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

6 November 2019

cites work

1 reference

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Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

21 January 2018

1 reference

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Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

21 January 2018

1 reference

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

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Mapping of the p53 and mdm-2 Interaction Domains

21 January 2018

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ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

21 January 2018

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

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Ubch9 conjugates SUMO but not ubiquitin

21 January 2018

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Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1

21 January 2018

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

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The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

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Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

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Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

21 January 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

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21 January 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

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Allosteric activation of latent p53 tetramers

21 January 2018

1 reference

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Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

1 reference

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

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21 January 2018

p53: puzzle and paradigm

1 reference

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Transcription factor-specific requirements for coactivators and their acetyltransferase functions

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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Is green fluorescent protein toxic to the living cells?

21 January 2018

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Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

21 January 2018

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

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mdm2 expression is induced by wild type p53 activity

21 January 2018

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7 January 2021

MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status

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7 January 2021

The CDKN2A (p16) gene and human cancer.

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7 January 2021

The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability

1 reference

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7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

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7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives.

1 reference

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7 January 2021

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203593

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10822382%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 November 2019

1031554726

0 references

1 reference