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Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer

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28 March 2020

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Europe PubMed Central

30 January 2021

8 February 2021

19 July 2021

Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27886118%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

organic chemistry

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0 references

histone deacetylase inhibitors

1 reference

30 January 2021

1 reference

8 February 2021

anti-inflammatory agent

1 reference

19 July 2021

Michael Schnekenburger

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27886118%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

4

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28 March 2020

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Hélène Losson

1

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Europe PubMed Central

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28 March 2020

Mario Dicato

3

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28 March 2020

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23 November 2016

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Europe PubMed Central

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28 March 2020

30 January 2021

8 February 2021

19 July 2021

4 references

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27886118%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

30 January 2021

8 February 2021

19 July 2021

21

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28 March 2020

11

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28 March 2020

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3 references

30 January 2021

8 February 2021

19 July 2021

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A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

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Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors

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FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

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21 January 2018

n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells

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Fiber-derived butyrate and the prevention of colon cancer

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Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway

1 reference

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21 January 2018

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

1 reference

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21 January 2018

Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition

1 reference

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21 January 2018

Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis

1 reference

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21 January 2018

Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase

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21 January 2018

Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.

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21 January 2018

Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors.

1 reference

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21 January 2018

Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.

1 reference

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21 January 2018

Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer.

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21 January 2018

Syntheses and biological activity of amamistatin B and analogs

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Diallyl disulfide (DADS) increases histone acetylation and p21(waf1/cip1) expression in human colon tumor cell lines

1 reference

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The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses

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Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases.

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Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells.

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Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway

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Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

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21 January 2018

Shaping the nuclear action of NF-kappaB

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TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation

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NOS2 regulation of NF-kappaB by S-nitrosylation of p65.

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21 January 2018

Inhibitors of NF-kappaB signaling: 785 and counting

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Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions

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21 January 2018

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

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Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65

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21 January 2018

HATs on and beyond chromatin

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21 January 2018

Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression

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21 January 2018

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65

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21 January 2018

Acetylation of histones and transcription-related factors

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21 January 2018

SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

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21 January 2018

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21 January 2018

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21 January 2018

Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle

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21 January 2018

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21 January 2018

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

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21 January 2018

The SIRT2 deacetylase regulates autoacetylation of p300

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21 January 2018

Hallmarks of Cancer: The Next Generation

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21 January 2018

Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer.

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21 January 2018

Superior antimitogenic and chemosensitization activities of the combination treatment of the histone deacetylase inhibitor apicidin and proteasome inhibitors on human colorectal cancer cells

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21 January 2018

Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101.

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21 January 2018

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma

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21 January 2018

The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells

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21 January 2018

Inhibition of the proliferation of acquired aromatase inhibitor-resistant breast cancer cells by histone deacetylase inhibitor LBH589 (panobinostat).

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21 January 2018

Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo.

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21 January 2018

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

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21 January 2018

Acetylation of Stat1 modulates NF-kappaB activity

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21 January 2018

Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of NF-kappaB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular insights into azumamide e histone deacetylases inhibitory activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of HDAC inhibitor FR235222-mediated IL-2 transcriptional repression in Jurkat cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors from the rhizomes of Zingiber zerumbet

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cysteine 38 holds the key to NF-κB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural chalcones as dual inhibitors of HDACs and NF-κB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aceroside VIII is a new natural selective HDAC6 inhibitor that synergistically enhances the anticancer activity of HDAC inhibitor in HT29 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Panobinostat (Farydak): A Novel Option for the Treatment of Relapsed Or Relapsed and Refractory Multiple Myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new antifungal antibiotic, trichostatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/27886118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.43.1524

Identifiers

10.3390/MOLECULES21111608

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27886118%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27886118%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PubMed publication ID

2 references

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27886118%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

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