(Q27671833)

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11 February 2020

title

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease (English)

1 reference

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11 February 2020

1 reference

inferred from abstract

1 reference

inferred from abstract

3C-like proteinase [SARS-Cov]

0 references

1 reference

4

1 reference

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11 February 2020

Jörg Rademann

5

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11 February 2020

6

Rolf Hilgenfeld

1 reference

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11 February 2020

author name string

Lili Zhu

1

1 reference

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11 February 2020

Shyla George

2

1 reference

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11 February 2020

Marco F Schmidt

3

1 reference

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11 February 2020

publication date

11 August 2011

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11 February 2020

1 reference

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11 February 2020

volume

92

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11 February 2020

issue

2

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11 February 2020

page(s)

204-212

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An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

11 February 2020

cites work

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Mutation of Glu-166 blocks the substrate-induced dimerization of SARS coronavirus main protease.

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

The CCP4 suite: programs for protein crystallography

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

The 1.8 A structure of the complex between chymostatin and Streptomyces griseus protease A. A model for serine protease catalytic tetrahedral intermediates

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Coot: model-building tools for molecular graphics

13 September 2020

1 reference

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Scaling and assessment of data quality

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

The substrate specificity of SARS coronavirus 3C-like proteinase

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

SARS CoV main proteinase: The monomer-dimer equilibrium dissociation constant

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery.

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Statistical and theoretical investigations on the directionality of nonbonded S...O interactions. Implications for molecular design and protein engineering

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide.

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Refinement of macromolecular structures by the maximum-likelihood method

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Non-hydrogen bond interactions involving the methionine sulfur atom.

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

UCSF Chimera--a visualization system for exploratory research and analysis

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

A graphical user interface to the CCP4 program suite

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Recent advances in targeting viral proteases for the discovery of novel antivirals

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

Design of wide-spectrum inhibitors targeting coronavirus main proteases

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase

13 September 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241

10.1016/J.ANTIVIRAL.2011.08.001

13 September 2020

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21854807%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PMC publication ID

7114241

0 references

1 reference