(Q27665370)

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14 January 2020

title

Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H (English)

1 reference

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14 January 2020

1

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14 January 2020

author name string

Chen Zhong

2

1 reference

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14 January 2020

Yingjie Peng

3

1 reference

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14 January 2020

Zheng Lai

4

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14 January 2020

Jianping Ding

5

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14 January 2020

publication date

26 October 2010

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14 January 2020

number of pages

13

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inferred from page(s)

published in

Cell Research

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14 January 2020

volume

20

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14 January 2020

issue

11

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14 January 2020

page(s)

1188-1200

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IDH1 and IDH2 mutations in gliomas

14 January 2020

cites work

1 reference

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IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

21 April 2017

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 April 2017

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Recurring mutations found by sequencing an acute myeloid leukemia genome

21 April 2017

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The consensus coding sequences of human breast and colorectal cancers

21 April 2017

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 April 2017

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Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

21 April 2017

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Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism

21 April 2017

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Structural studies ofSaccharomyces cerevesiaemitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction

21 April 2017

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Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase

21 April 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 April 2017

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Refinement of macromolecular structures by the maximum-likelihood method

21 April 2017

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 April 2017

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Coot: model-building tools for molecular graphics

21 April 2017

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Main-chain bond lengths and bond angles in protein structures

21 April 2017

1 reference

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

21 April 2017

1 reference

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Analysis of the IDH1 codon 132 mutation in brain tumors

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

21 January 2018

1 reference

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Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

21 January 2018

1 reference

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Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children.

21 January 2018

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Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

Widespread monoallelic expression on human autosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

Structure of the monomeric isocitrate dehydrogenase: evidence of a protein monomerization by a domain duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

Critical Role of Lys212 and Tyr140 in Porcine NADP-dependent Isocitrate Dehydrogenase

21 January 2018

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Kinetic mechanism of Escherichia coli isocitrate dehydrogenase.

21 January 2018

1 reference

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Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP-dependent isocitrate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

Identification by mutagenesis of arginines in the substrate binding site of the porcine NADP-dependent isocitrate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

7 January 2021

Evaluation by site-directed mutagenesis of aspartic acid residues in the metal site of pig heart NADP-dependent isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

7 January 2021

Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

7 January 2021

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.145

7 January 2021

Identifiers

DOI

10.1038/CR.2010.145

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20975740%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 January 2020

1015734513

0 references

1 reference