(Q27552780)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32917

Protein Ste5, Fus3-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Scaffold protein Ste5, Fus3-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

MAP-kinase scaffold activity

phosphatidylinositol-4,5-bisphosphate binding

1 reference

14 February 2019

Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

kinase binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

1 reference

14 February 2019

IEA

protein binding

9 references

14 February 2019

Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

Recognition of non-canonical peptides by the yeast Fus1p SH3 domain: elucidation of a common mechanism for diverse SH3 domain specificities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

G-protein beta-subunit binding

1 reference

14 February 2019

Association of the Yeast Pheromone Response G Protein βγ Subunits with the Map Kinase Scaffold Ste5p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

MAP-kinase scaffold activity

Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

cell component

nucleus

1 reference

14 February 2019

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

mating projection tip

plasma membrane

plasma membrane

1 reference

14 February 2019

Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

mating projection tip membrane

1 reference

14 February 2019

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

regulation of transposition, RNA-mediated

biological process

1 reference

14 February 2019

Posttranslational regulation of Ty1 retrotransposition by mitogen-activated protein kinase Fus3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

pheromone-dependent signal transduction involved in conjugation with cellular fusion

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

14 February 2019

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

response to pheromone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

1 reference

14 February 2019

positive regulation of protein phosphorylation

IEA

1 reference

14 February 2019

The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

invasive growth in response to glucose limitation

1 reference

14 February 2019

Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

negative regulation of MAPK cascade

1 reference

14 February 2019

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

positive regulation of MAPK cascade

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32917

Scaffold protein Ste5, Fus3-binding domain

IEA

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32917

Protein Ste5, Fus3-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32917

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference