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Non-Alcoholic Steatohepatitis: Limited Available Treatment Options but Promising Drugs in Development and Recent Progress Towards a Regulatory Approval Pathway

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22 August 2022

Non-Alcoholic Steatohepatitis: Limited Available Treatment Options but Promising Drugs in Development and Recent Progress Towards a Regulatory Approval Pathway (English)

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1 reference

17 December 2020

steatohepatitis

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metabolic dysfunction–associated steatotic liver disease

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21 March 2019

20 June 2019

6 August 2019

19 September 2019

7 October 2019

8 September 2020

12 November 2020

pharmaceutical preparation

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6 August 2019

biomedical investigative technique

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19 September 2019

human digestive system

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7 October 2019

investigational drugs

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8 September 2020

gastrointestinal agent

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12 November 2020

non-alcoholic steatohepatitis

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based on heuristic

inferred from title

Claudia Filozof

1

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Europe PubMed Central

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14 June 2020

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Barry J Goldstein

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14 June 2020

Richard N Williams

3

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14 June 2020

Arun Sanyal

4

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14 June 2020

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August 2015

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1 August 2015

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21 March 2019

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12 November 2020

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22 August 2022

10 references

21 March 2019

20 June 2019

6 August 2019

19 September 2019

7 October 2019

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201461%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

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75

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14 June 2020

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14 June 2020

1373-1392

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14 June 2020

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Creative Commons Attribution-NonCommercial

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21 March 2019

20 June 2019

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19 September 2019

7 October 2019

8 September 2020

12 November 2020

17 December 2020

22 August 2022

on focus list of Wikimedia project

0 references

Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

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Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

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Bariatric surgery for non-alcoholic steatohepatitis in obese patients

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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease

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Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice

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Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

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Liver fibrosis in overweight patients

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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

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The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

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Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers

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Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality

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Steatohepatitis: A tale of two “hits”?

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7 April 2017

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

1 reference

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Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adults

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Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials

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Long-term follow-up of patients with NAFLD and elevated liver enzymes

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Design and validation of a histological scoring system for nonalcoholic fatty liver disease

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Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

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Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity

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From adaptive licensing to adaptive pathways: delivering a flexible life-span approach to bring new drugs to patients.

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Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity

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Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop

1 reference

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28 September 2017

Serum cytokeratin 18 fragment level as a noninvasive biomarker for non-alcoholic fatty liver disease

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Bariatric surgery and non-alcoholic Fatty liver disease: current and potential future treatments

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Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease

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The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease

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Noninvasive Diagnosis of NASH and Liver Fibrosis Within the Spectrum of NAFLD.

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Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease--the role of transient elastography and plasma cytokeratin-18 fragments

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Noninvasive biomarkers for the diagnosis of steatohepatitis and advanced fibrosis in NAFLD.

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Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

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Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease

1 reference

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Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population

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28 September 2017

Fatty infiltration of liver in hyperlipidemic patients

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Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions

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Catalyzing the Critical Path Initiative: FDA's progress in drug development activities

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31 May 2018

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

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31 May 2018

Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

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31 May 2018

Long-term mortality in nonalcoholic fatty liver disease: is liver histology of any prognostic significance?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

31 May 2018

Transient elastography in patients with non-alcoholic fatty liver disease (NAFLD).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

31 May 2018

Selection and outcome of living donors for adult to adult right lobe transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

31 May 2018

Hepatic effects of dietary weight loss in morbidly obese subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

31 May 2018

NASH: A global health problem

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Predictors of nonalcoholic steatohepatitis (NASH) in obese patients undergoing gastric bypass

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

The histologic spectrum of liver disease in African-American, non-Hispanic white, and Hispanic obesity surgery patients

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Role of ethnicity in overweight and obese patients with nonalcoholic steatohepatitis.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Long-term follow-up of patients with nonalcoholic fatty liver

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Upper normal threshold of serum alanine aminotransferase in identifying individuals at risk for chronic liver disease.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

A biomarker panel for non-alcoholic steatohepatitis (NASH) and NASH-related fibrosis

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Magnetic resonance elastography for the noninvasive staging of liver fibrosis.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Therapeutic effects of restricted diet and exercise in obese patients with fatty liver

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Dietary fat content modifies liver fat in overweight nondiabetic subjects

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Effects of combined exenatide and pioglitazone therapy on hepatic fat content in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Could inflammatory markers help diagnose nonalcoholic steatohepatitis?

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Non-invasive markers to predict the liver fibrosis in non-alcoholic fatty liver disease.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease

1 reference

https://api.crossref.org/works/10.1007%2FS40265-015-0437-3

21 January 2018

No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

28 November 2018

TNF-α messenger ribonucleic acid (mRNA) in patients with nonalcoholic steatohepatitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

28 November 2018

Predictive factors for nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

28 November 2018

Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

28 November 2018

Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4532706

28 November 2018

Accelerated access to innovative medicines for patients in need

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High Visceral Fat Mass and High Liver Fat Are Associated with Resistance to Lifestyle Intervention*

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum ferritin is a discriminant marker for both fibrosis and inflammation in histologically proven non-alcoholic fatty liver disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rimonabant improves cholesterol, insulin resistance and markers of non-alcoholic fatty liver in morbidly obese patients: a retrospective cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Usefulness of a combined evaluation of the serum adiponectin level, HOMA-IR, and serum type IV collagen 7S level to predict the early stage of nonalcoholic steatohepatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient elastography with a new probe for obese patients for non-invasive staging of non-alcoholic steatohepatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26201461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S40265-015-0437-3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201461%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Dimensions Publication ID

0 references

release_3nchtm45wfcejbr26nvvscypuu

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201461%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201461%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

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