(Q24810573)

15 November 2016

title

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants (English)

1 reference

PubMed publication ID

15 November 2016

1

0 references

Matthew Meyerson

11

object named as

Matthew Meyerson

0 references

Pasi A Jänne

4

object named as

Pasi A Jänne

0 references

William C Hahn

9

object named as

William C Hahn

0 references

author name string

Tzu-Hsiu Chen

2

0 references

Whei Feng

3

0 references

James V Alvarez

5

0 references

Mauro Zappaterra

6

0 references

Sara E Bulmer

7

0 references

David A Frank

8

0 references

William R Sellers

Creative Commons Attribution 4.0 International

10

0 references

language of work or name

English

0 references

publication date

November 2005

0 references

published in

PLOS MEDICINE

0 references

volume

2

0 references

issue

11

0 references

page(s)

e313

0 references

copyright license

start time

4 October 2005

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

7 April 2017

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Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells

7 April 2017

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

7 April 2017

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

7 April 2017

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

7 April 2017

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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

7 April 2017

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Creation of human tumour cells with defined genetic elements

7 April 2017

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

7 April 2017

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Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

7 April 2017

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Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

7 April 2017

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The ErbB signaling network: receptor heterodimerization in development and cancer

7 April 2017

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

7 April 2017

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Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence

7 April 2017

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Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer.

28 September 2017

1 reference

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Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm

28 September 2017

1 reference

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28 September 2017

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Immortalization and transformation of primary human airway epithelial cells by gene transfer.

28 September 2017

1 reference

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Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240052

Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785)

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187797

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187797

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187797

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PMED.0020313

1 reference

1 reference

1 reference

PubMed publication ID

16187797

1 reference