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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
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Europe PubMed Central
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3063353
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
review article
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Europe PubMed Central
title
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
(English)
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Europe PubMed Central
PMC publication ID
3063353
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
author
Marie Cargnello
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1
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Europe PubMed Central
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3063353
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
Philippe P. Roux
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2
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Europe PubMed Central
PMC publication ID
3063353
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
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Marie Cargnello
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1
0 references
Philippe P Roux
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2
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language of work or name
English
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publication date
1 March 2011
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Europe PubMed Central
PMC publication ID
3063353
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
published in
Microbiology and Molecular Biology Reviews
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Europe PubMed Central
PMC publication ID
3063353
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
volume
75
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stated in
Europe PubMed Central
PMC publication ID
3063353
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3063353
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
page(s)
50-83
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stated in
Europe PubMed Central
PMC publication ID
3063353
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
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Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)
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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
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Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
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The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization
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Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity
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Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation
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MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
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Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway
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Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
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The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
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Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
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Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin
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7 April 2017
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
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7 April 2017
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts
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7 April 2017
ERK8, a new member of the mitogen-activated protein kinase family
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7 April 2017
C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival
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7 April 2017
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
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7 April 2017
Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2
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7 April 2017
Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
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7 April 2017
The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells
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7 April 2017
C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)
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7 April 2017
Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity
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7 April 2017
Rsk1 mediates a MEK-MAP kinase cell survival signal
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7 April 2017
A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation
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7 April 2017
The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase
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7 April 2017
Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3
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7 April 2017
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
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7 April 2017
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
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7 April 2017
Cloning and characterization of RLPK, a novel RSK-related protein kinase
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7 April 2017
PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.
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7 April 2017
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)
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PubMed Central
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7 April 2017
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
1 reference
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PubMed Central
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7 April 2017
PRAK, a novel protein kinase regulated by the p38 MAP kinase
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PubMed Central
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7 April 2017
Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
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PubMed Central
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7 April 2017
pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063353
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7 April 2017
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7 April 2017
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7 April 2017
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
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7 April 2017
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7 April 2017
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7 April 2017
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7 April 2017
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7 April 2017
A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
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7 April 2017
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7 April 2017
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
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7 April 2017
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7 April 2017
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7 April 2017
A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity
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7 April 2017
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7 April 2017
Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase
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7 April 2017
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7 April 2017
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
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7 April 2017
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
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7 April 2017
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3
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7 April 2017
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
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7 April 2017
Primary Structure of BMK1: A New Mammalian MAP Kinase
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7 April 2017
RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation
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7 April 2017
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
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7 April 2017
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7 April 2017
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
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7 April 2017
Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export
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7 April 2017
TSC2 mediates cellular energy response to control cell growth and survival
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7 April 2017
The protein kinases Rck1 and Rck2 inhibit meiosis in budding yeast
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7 April 2017
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7 April 2017
NF-kappaB RelA phosphorylation regulates RelA acetylation
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7 April 2017
MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment
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7 April 2017
The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2
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7 April 2017
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation
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7 April 2017
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
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7 April 2017
Atypical mitogen-activated protein kinases: structure, regulation and functions
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7 April 2017
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
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7 April 2017
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
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7 April 2017
Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway
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7 April 2017
MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1
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7 April 2017
Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1
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7 April 2017
Wnt activates the Tak1/Nemo-like kinase pathway
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7 April 2017
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism
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7 April 2017
RSK2 activity is regulated by its interaction with PEA-15
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7 April 2017
Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)
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7 April 2017
Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A
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7 April 2017
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
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7 April 2017
Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase
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7 April 2017
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation
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7 April 2017
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
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7 April 2017
Tumor necrosis factor receptor-associated factors (TRAFs)
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7 April 2017
Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2
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7 April 2017
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
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7 April 2017
FRET-based detection of different conformations of MK2.
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7 April 2017
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
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7 April 2017
Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains
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7 April 2017
MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells
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7 April 2017
Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta
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7 April 2017
Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases
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7 April 2017
ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions
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7 April 2017
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7 April 2017
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
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7 April 2017
Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation
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7 April 2017
Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
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7 April 2017
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
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7 April 2017
LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils
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7 April 2017
Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases
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7 April 2017
The signal-dependent coactivator CBP is a nuclear target for pp90RSK
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27 September 2017
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells
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27 September 2017
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development
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27 September 2017
JNK signaling in apoptosis
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27 September 2017
Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells
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27 September 2017
Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival
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27 September 2017
Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance
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27 September 2017
The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
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27 September 2017
Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells
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27 September 2017
Specificity of signaling from MAPKs to MAPKAPKs: kinases' tango nuevo
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27 September 2017
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27 September 2017
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27 September 2017
The RSK factors of activating the Ras/MAPK signaling cascade
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27 September 2017
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.
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27 September 2017
Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation
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27 September 2017
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport
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27 September 2017
The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5.
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27 September 2017
Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.
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27 September 2017
Dissecting eIF4E action in tumorigenesis
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27 September 2017
The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha
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27 September 2017
Critical role for Rsk2 in T-lymphocyte activation
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27 September 2017
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.
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27 September 2017
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation
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27 September 2017
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway
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27 September 2017
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.
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27 September 2017
Characterization of the activity of human MAP kinase-interacting kinase Mnk1b.
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27 September 2017
G protein regulation of MAPK networks
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27 September 2017
Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin
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27 September 2017
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
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27 September 2017
Aberrant expression of X-linked genes RbAp46, Rsk4, and Cldn2 in breast cancer
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27 September 2017
A clickable inhibitor reveals context-dependent autoactivation of p90 RSK
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27 September 2017
HMG chromosomal proteins in development and disease
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27 September 2017
Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.
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27 September 2017
The MEK/ERK cascade: from signaling specificity to diverse functions
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27 September 2017
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo
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27 September 2017
Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior
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27 September 2017
The VASP-Spred-Sprouty domain puzzle
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27 September 2017
Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase
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27 September 2017
ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.
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27 September 2017
ERK1c regulates Golgi fragmentation during mitosis
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27 September 2017
The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IkappaB kinase complex
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27 September 2017
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element
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27 September 2017
Regulation of sprouty stability by Mnk1-dependent phosphorylation
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27 September 2017
MAPKAP kinases - MKs - two's company, three's a crowd
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27 September 2017
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions
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27 September 2017
Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.
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27 September 2017
The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling
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27 September 2017
p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression
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27 September 2017
Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties
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27 September 2017
Structural bioinformatics-based design of selective, irreversible kinase inhibitors
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27 September 2017
Differential localization of MAPK-activated protein kinases RSK1 and MSK1 in mouse brain
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27 September 2017
p90Rsk is not involved in cytostatic factor arrest in mouse oocytes
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27 September 2017
The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation
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27 September 2017
Essential role of RSK2 in c-Fos-dependent osteosarcoma development
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27 September 2017
Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation
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27 September 2017
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27 September 2017
Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.
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27 September 2017
Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics
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27 September 2017
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27 September 2017
Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice
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27 September 2017
Stem cells and cancer; the polycomb connection
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27 September 2017
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
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27 September 2017
DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death
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27 September 2017
p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cdelta
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27 September 2017
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome
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27 September 2017
P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity
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27 September 2017
p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.
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27 September 2017
ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway
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27 September 2017
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site
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27 September 2017
Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination
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27 September 2017
Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling
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27 September 2017
MSK1 and MSK2 mediate mitogen- and stress-induced phosphorylation of histone H3: a controversy resolved
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27 September 2017
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27 September 2017
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27 September 2017
Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis
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27 September 2017
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27 September 2017
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27 September 2017
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27 September 2017
Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning
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27 September 2017
Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells
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27 September 2017
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27 September 2017
Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress
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27 September 2017
Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase
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27 September 2017
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27 September 2017
The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor
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27 September 2017
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27 September 2017
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27 September 2017
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27 September 2017
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27 September 2017
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27 September 2017
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
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27 September 2017
Exploring the molecular basis of Bardet-Biedl syndrome
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27 September 2017
Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1
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27 September 2017
Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap.
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27 September 2017
Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation
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27 September 2017
Mutations in the X-linked RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome
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27 September 2017
Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice
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27 September 2017
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27 September 2017
Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function
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27 September 2017
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27 September 2017
Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor
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27 September 2017
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation
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27 September 2017
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene
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27 September 2017
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.
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27 September 2017
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
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27 September 2017
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A transcript map of an 800-kb region on human chromosome 11q13, part of the candidate region for SCA5 and BBS1.
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27 September 2017
Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: a possible factor regulating synaptic protein synthesis
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27 September 2017
Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase
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27 September 2017
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways
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27 September 2017
MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase
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27 September 2017
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
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27 September 2017
The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism
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27 September 2017
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27 September 2017
Sounding the alarm: protein kinase cascades activated by stress and inflammation
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27 September 2017
Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade
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27 September 2017
Evidence for two catalytically active kinase domains in pp90rsk
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27 September 2017
ERK3 is a constitutively nuclear protein kinase
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27 September 2017
The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.
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27 September 2017
Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo
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27 September 2017
Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.
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27 September 2017
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.
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27 September 2017
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27 September 2017
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27 September 2017
A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases
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27 September 2017
Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase
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27 September 2017
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27 September 2017
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
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27 September 2017
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27 September 2017
Phosphorylation of c-Fos at the C-terminus enhances its transforming activity.
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27 September 2017
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
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27 September 2017
Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.
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27 September 2017
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.
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30 May 2018
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.
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30 May 2018
p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase.
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30 May 2018
Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress
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30 May 2018
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
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30 May 2018
Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis
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30 May 2018
Molecular interpretation of ERK signal duration by immediate early gene products
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30 May 2018
Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs
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30 May 2018
Two distinct forms of MAPKAP kinase-2 in adult cardiac ventricular myocytes.
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30 May 2018
Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa.
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30 May 2018
The protein kinase p90 rsk as an essential mediator of cytostatic factor activity
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30 May 2018
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.
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30 May 2018
HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus
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30 May 2018
A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1.
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30 May 2018
p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells.
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30 May 2018
Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk.
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30 May 2018
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro
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30 May 2018
Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase
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30 May 2018
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling
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30 May 2018
Functional domains and phosphorylation of the orphan receptor Nur77.
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30 May 2018
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
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30 May 2018
pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity
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30 May 2018
MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase
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30 May 2018
A two-step inactivation mechanism of Myt1 ensures CDK1/cyclin B activation and meiosis I entry
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28 November 2018
C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis
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28 November 2018
Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration
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28 November 2018
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
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28 November 2018
Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.
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28 November 2018
14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization.
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28 November 2018
A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs
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28 November 2018
Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs
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28 November 2018
Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4.
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28 November 2018
The MAP kinase ERK5 binds to and phosphorylates p90 RSK.
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28 November 2018
Mnk is a negative regulator of cap-dependent translation in Aplysia neurons.
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28 November 2018
Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.
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28 November 2018
Phosphorylation of Cdc25C by pp90Rsk contributes to a G2 cell cycle arrest in Xenopus cycling egg extracts
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28 November 2018
The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task.
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28 November 2018
Chromosomal protein HMGN1 modulates histone H3 phosphorylation
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28 November 2018
Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry
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28 November 2018
Induction of p97MAPK expression regulates collagen mediated inhibition of proliferation and migration in human squamous cell carcinoma lines.
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28 November 2018
AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties
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28 November 2018
Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization
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28 November 2018
Activation of cyclin D1 expression by the ERK5 cascade
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28 November 2018
Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.
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28 November 2018
Phosphorylation-dependent structural alterations in the small hsp30 chaperone are associated with cellular recovery.
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28 November 2018
Persistent ERK phosphorylation negatively regulates cAMP response element-binding protein (CREB) activity via recruitment of CREB-binding protein to pp90RSK.
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28 November 2018
Histone H3 phosphorylation during Xenopus oocyte maturation: regulation by the MAP kinase/p90Rsk pathway and uncoupling from DNA condensation.
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28 November 2018
Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation
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28 November 2018
Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection
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28 November 2018
A constitutively active form of the protein kinase p90Rsk1 is sufficient to trigger the G2/M transition in Xenopus oocytes
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28 November 2018
Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients
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28 November 2018
MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells.
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28 November 2018
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway
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28 November 2018
Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues
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28 November 2018
The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila.
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28 November 2018
Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk
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28 November 2018
JIL-1: a novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila
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28 November 2018
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.
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28 November 2018
A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1.
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28 November 2018
Heat shock protein 27 kDa expression and phosphorylation regulates endothelial cell migration
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28 November 2018
Identification of mitogen-activated protein kinase-activated protein kinase-2 as a vimentin kinase activated by okadaic acid in 9L rat brain tumor cells
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28 November 2018
Phosphorylation of alphaB-crystallin in mitotic cells and identification of enzymatic activities responsible for phosphorylation.
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28 November 2018
EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2
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28 November 2018
LK6, a short lived protein kinase in Drosophila that can associate with microtubules and centrosomes
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28 November 2018
Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene
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28 November 2018
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
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28 November 2018
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins
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28 November 2018
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
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https://pubmed.ncbi.nlm.nih.gov/21372320
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Selective targeting of MAPKs to the ETS domain transcription factor SAP-1
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https://pubmed.ncbi.nlm.nih.gov/21372320
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization
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https://pubmed.ncbi.nlm.nih.gov/21372320
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1
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https://pubmed.ncbi.nlm.nih.gov/21372320
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6
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https://pubmed.ncbi.nlm.nih.gov/21372320
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Characterization of a Protein Kinase that Phosphorylates Serine 189 of the Mitogen-activated Protein Kinase Homolog ERK3
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Signalling pathways which regulate eIF4E
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identification of serine 380 as the major site of autophosphorylation of Xenopus pp90rsk
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Angiotensin II stimulates p90rsk in vascular smooth muscle cells. A potential Na(+)-H+ exchanger kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identification of a cytoplasmic-retention sequence in ERK2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A new cellular signaling mechanism for angiotensin II activation of NF-kappaB: An IkappaB-independent, RSK-mediated phosphorylation of p65
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IkappaB kinase and ribosomal kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Divergent Functional Roles for p90 Kinase Domains
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
JNK2 is a positive regulator of the cJun transcription factor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Does MK5 reconcile classical and atypical MAP kinases?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Casein kinase 2 interacts with human mitogen- and stress-activated protein kinase MSK1 and phosphorylates it at multiple sites
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21372320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cloning, characterization, and modeling of mouse and human guanylate kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1128%2FMMBR.00031-10
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1128/MMBR.00031-10
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
549028
stated in
Europe PubMed Central
PMC publication ID
3063353
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
OpenCitations bibliographic resource ID
549028
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
549028
PMC publication ID
3063353
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
549028
stated in
Europe PubMed Central
PMC publication ID
3063353
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PubMed publication ID
21372320
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
549028
stated in
Europe PubMed Central
PMC publication ID
3063353
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
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