(Q24537701)

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Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.

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14 December 2019

Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38 (English)

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14 December 2019

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Andrew R. Clark

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14 December 2019

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Marina Lasa

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14 December 2019

Sonya M Abraham

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14 December 2019

Christine Boucheron

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14 December 2019

Jeremy Saklatvala

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14 December 2019

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1 November 2002

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14 December 2019

Molecular and Cellular Biology

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14 December 2019

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14 December 2019

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14 December 2019

7802-7811

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14 December 2019

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

1 reference

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24 March 2017

Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation

1 reference

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24 March 2017

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

1 reference

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24 March 2017

Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5

1 reference

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24 March 2017

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

1 reference

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24 March 2017

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

1 reference

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24 March 2017

The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase

1 reference

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24 March 2017

The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor

1 reference

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24 March 2017

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1 reference

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24 March 2017

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

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24 March 2017

Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

24 March 2017

Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation

1 reference

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24 March 2017

Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1

1 reference

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24 March 2017

Mammalian MAP kinase signalling cascades

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

24 March 2017

Dexamethasone alters arachidonate release from human epithelial cells by induction of p11 protein synthesis and inhibition of phospholipase A2 activity

1 reference

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24 March 2017

Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)

1 reference

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24 March 2017

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

1 reference

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24 March 2017

The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression

1 reference

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24 March 2017

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

1 reference

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24 March 2017

Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

24 March 2017

Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells

1 reference

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24 March 2017

A conserved docking motif in MAP kinases common to substrates, activators and regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

7 April 2017

Regulation of transcription by MAP kinase cascades

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

7 April 2017

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

7 April 2017

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Cross-talk between pro-inflammatory transcription factors and glucocorticoids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38.

1 reference

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27 September 2017

Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade

1 reference

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27 September 2017

Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Molecular mechanisms of glucocorticoid action: what is important?

1 reference

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27 September 2017

Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

1 reference

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27 September 2017

Dual specificity phosphatases: a gene family for control of MAP kinase function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Protein kinase C epsilon is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages

1 reference

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27 September 2017

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Organization and regulation of mitogen-activated protein kinase signaling pathways

1 reference

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27 September 2017

DNA binding of the glucocorticoid receptor is not essential for survival

1 reference

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27 September 2017

Inhibition of mitogen-activated protein kinase activity and proliferation of an early osteoblast cell line (MBA 15.4) by dexamethasone: role of protein phosphatases

1 reference

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27 September 2017

Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

1 reference

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27 September 2017

Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

27 September 2017

Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo

1 reference

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27 September 2017

Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells

1 reference

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27 September 2017

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts

1 reference

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27 September 2017

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

1 reference

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27 September 2017

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

1 reference

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27 September 2017

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

1 reference

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27 September 2017

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

1 reference

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30 May 2018

The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.

1 reference

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30 May 2018

Glucocorticoids stimulate p21 gene expression by targeting multiple transcriptional elements within a steroid responsive region of the p21waf1/cip1 promoter in rat hepatoma cells

1 reference

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30 May 2018

Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: mediation by decreased mRNA stability.

1 reference

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30 May 2018

Purification and characterization of human interleukin-1 beta expressed in recombinant Escherichia coli.

1 reference

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30 May 2018

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.

1 reference

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30 May 2018

Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability.

1 reference

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29 November 2018

Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism

1 reference

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29 November 2018

New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?

1 reference

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29 November 2018

Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts.

1 reference

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29 November 2018

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1 reference

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29 November 2018

The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134716

29 November 2018

Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

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inferred from PubMed ID database lookup

Adhesion to fibronectin enhances MKP-1 activation in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

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inferred from PubMed ID database lookup

Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8, and IL-6, but not of M-CSF in human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

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inferred from PubMed ID database lookup

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

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Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

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Inhibition by dexamethasone of antigen-induced c-Jun N-terminal kinase activation in rat basophilic leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoid receptor down-Regulates c-jun amino terminal kinases induced by tumor necrosis factor ? in fetal rat hepatocyte primary cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased mRNA stability as a mechanism of glucocorticoid-mediated inhibition of vascular endothelial growth factor gene expression by cultured keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal

1 reference

https://pubmed.ncbi.nlm.nih.gov/12391149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.22.22.7802-7811.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12391149%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12391149%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12391149%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

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