(Q24320004)

2

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Wei H Tan

3

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Juin H Chai

4

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Xueying Wang

Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability

5

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language of work or name

English

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publication date

October 2011

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published in

FEBS Journal

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volume

278

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issue

19

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page(s)

3724-38

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cites work

1 reference

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p53 governs telomere regulation feedback too, via TRF2.

21 January 2018

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The effect of telomerase template antagonist GRN163L on bone-marrow-derived rat mesenchymal stem cells is reversible and associated with altered expression of cyclin d1, cdk4 and cdk6.

21 January 2018

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7 January 2021

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

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7 January 2021

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

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7 January 2021

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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7 January 2021

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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7 January 2021

DNA damage foci at dysfunctional telomeres

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7 January 2021

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

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7 January 2021

Actions of human telomerase beyond telomeres

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7 January 2021

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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7 January 2021

Telomerase therapeutics for cancer: challenges and new directions

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7 January 2021

Inhibitor of cyclooxygenase-2 induces cell-cycle arrest in the epithelial cancer cell line via up-regulation of cyclin dependent kinase inhibitor p21

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7 January 2021

Targeting telomerase for cancer therapeutics

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7 January 2021

53BP1: function and mechanisms of focal recruitment

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7 January 2021

NF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival

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7 January 2021

A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

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7 January 2021

BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cells

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Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA.

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7 January 2021

Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells

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7 January 2021

Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules

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7 January 2021

Different telomere damage signaling pathways in human and mouse cells

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7 January 2021

Telomerase-based therapies emerging slowly

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7 January 2021

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

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7 January 2021

Telomerase activity in human cancer.

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7 January 2021

Normal human chromosomes have long G-rich telomeric overhangs at one end

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7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

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7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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7 January 2021

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

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7 January 2021

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7 January 2021

Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA.

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7 January 2021

Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells

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7 January 2021

Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence.

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7 January 2021

ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells

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7 January 2021

Correlating breakage-fusion-bridge events with the overall chromosomal instability and in vitro karyotype evolution in prostate cancer

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7 January 2021

Life and death in cancer. GADD45 alpha and gamma are critical regulators of NF-kappaB mediated escape from programmed cell death

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