Wikidata

(Q21980210)

English

T-box 1

mammalian protein found in Mus musculus

  • testis-specific T-box protein
  • T-box protein 1
  • Tbx1
  • T-box transcription factor TBX1
In more languages
default for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
5 references
retrieved
14 February 2019
stated in
Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IPI
retrieved
14 February 2019
stated in
Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IPI
retrieved
14 February 2019
stated in
Ash2l interacts with Tbx1 and is required during early embryogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IPI
retrieved
14 February 2019
stated in
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IPI
retrieved
14 February 2019
stated in
Interaction between Tbx1 and Hoxd10 and connection with TGFβ-BMP signal pathway during kidney development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IPI
cell component
nucleus
determination method or standard
IDA
ISS
IEA
ISO
6 references
retrieved
14 February 2019
stated in
Isolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 gene
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IEA
retrieved
14 February 2019
stated in
Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IDA
retrieved
14 February 2019
stated in
The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IDA
biological process
positive regulation of epithelial cell proliferation
determination method or standard
IMP
5 references
retrieved
14 February 2019
stated in
Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
heart development
determination method or standard
IGI
ISS
IMP
ISO
9 references
retrieved
14 February 2019
stated in
Isolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 gene
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
ISO
retrieved
14 February 2019
stated in
Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IGI
retrieved
14 February 2019
stated in
Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IGI
positive regulation of transcription by RNA polymerase II
determination method or standard
IDA
IGI
IMP
5 references
retrieved
14 February 2019
stated in
Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IGI
retrieved
14 February 2019
stated in
Ash2l interacts with Tbx1 and is required during early embryogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IGI
retrieved
14 February 2019
stated in
Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IDA
retrieved
14 February 2019
stated in
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IDA
pharyngeal system development
determination method or standard
ISS
IGI
IMP
ISO
5 references
retrieved
14 February 2019
stated in
Isolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 gene
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
ISO
retrieved
14 February 2019
stated in
Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice
GOA
curator
UniProt
UniProt protein ID
P70323
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IMP
retrieved
14 February 2019
stated in
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IGI
positive regulation of transcription, DNA-templated
determination method or standard
IDA
ISO
5 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
ISO
retrieved
14 February 2019
stated in
Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IDA
retrieved
14 February 2019
stated in
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IDA
retrieved
14 February 2019
stated in
Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IDA
retrieved
14 February 2019
stated in
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323
determination method or standard
IDA

Identifiers

 
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