(Q21174672)

English

NADH:ubiquinone oxidoreductase subunit A1

mammalian protein found in Homo sapiens

CI-MWFE
NADH:ubiquinone oxidoreductase (complex 1)
type I dehydrogenase
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
complex I MWFE subunit
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
NADH-ubiquinone oxidoreductase MWFE subunit
NADH oxidoreductase subunit MWFE
complex I-MWFE
NDUFA1

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Statements

1 reference

13 November 2019

NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15239

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

13 November 2019

1 reference

13 November 2019

NADH dehydrogenase (ubiquinone) activity

determination method or standard

NAS

TAS

cell component

integral component of membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IEA

mitochondrion

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IEA

retrieved

8 April 2019

stated in

Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IDA

mitochondrial respiratory chain complex I

determination method or standard

4 references

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

NAS

retrieved

8 April 2019

stated in

Accessory subunits are integral for assembly and function of human mitochondrial complex I.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IDA

retrieved

8 April 2019

stated in

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IDA

retrieved

8 April 2019

stated in

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IDA

respirasome

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IEA

membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IEA

mitochondrial membranes

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IDA

cytosol

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method or standard

IDA

biological process

mitochondrial electron transport, NADH to ubiquinone

determination method or standard

NAS

1 reference

retrieved

1 January 2018

stated in

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15239&geneProductId=UniProtKB:O15239

determination method or standard

NAS

physically interacts with

metformin

object of statement has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1431

metformin hydrochloride

object of statement has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1703

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

(Q21174672)

NADH:ubiquinone oxidoreductase subunit A1

Statements

Identifiers

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