Wikidata

(Q21123095)

English

NK2 homeobox 5

mammalian protein found in Homo sapiens

  • homeobox protein CSX
  • homeobox protein NK-2 homolog E
  • homeobox protein NKX 2-5
  • NKX2-5
  • cardiac-specific homeobox 1
  • NK2 transcription factor related, locus 5
  • homeobox protein Nkx-2.5
  • Cardiac-specific homeobox
  • NKX 2-5
  • tinman paralog
In more languages
default values for all languages
No label defined

No description defined

Statements

molecular function
DNA-binding transcription factor activity
determination method
IDA
IEA
IMP
7 references
retrieved
7 November 2018
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
7 November 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IEA
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IEA
retrieved
7 November 2018
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
UniProt
UniProt protein ID
P52952
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
7 November 2018
stated in
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
7 November 2018
stated in
Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
7 November 2018
stated in
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IDA
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
P52952
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IPI
retrieved
8 April 2019
stated in
Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein
GOA
curator
UniProt
UniProt protein ID
P52952
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IPI
retrieved
8 April 2019
stated in
Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5
GOA
curator
UniProt
UniProt protein ID
P52952
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IPI
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
UniProt
UniProt protein ID
P52952
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IPI
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IPI
retrieved
8 April 2019
stated in
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IPI
DNA-binding transcription factor activity
determination method
IBA
IDA
IEA
IMP
8 references
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IEA
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
UniProt
UniProt protein ID
P52952
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
8 April 2019
stated in
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
8 April 2019
stated in
Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
8 April 2019
stated in
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IBA
cell component
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
ISS
IEA
IMP
10 references
retrieved
7 November 2018
stated in
Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
ISS
retrieved
7 November 2018
stated in
Common arterial trunk associated with a homeodomain mutation of NKX2.6
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
7 November 2018
stated in
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
7 November 2018
stated in
MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
7 November 2018
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
7 November 2018
stated in
Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IGI
retrieved
7 November 2018
stated in
The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IGI
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IEA
retrieved
7 November 2018
stated in
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
7 November 2018
stated in
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IBA
IDA
IEA
IGI
IMP
ISS
11 references
retrieved
8 April 2019
stated in
Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
ISS
retrieved
8 April 2019
stated in
Common arterial trunk associated with a homeodomain mutation of NKX2.6
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
8 April 2019
stated in
MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
8 April 2019
stated in
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IMP
retrieved
8 April 2019
stated in
Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IGI
retrieved
8 April 2019
stated in
The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IEA
retrieved
8 April 2019
stated in
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
8 April 2019
stated in
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952
determination method
IBA

Identifiers

 
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