Wikidata

(Q21119993)

English

Translocated promoter region, nuclear basket protein

mammalian protein found in Homo sapiens

  • translocated promoter region (to activated MET oncogene)
  • translocated promoter region protein
  • tumor potentiating region
  • nucleoprotein TPR
  • nuclear pore complex-associated protein TPR
  • Translocated promoter region
  • TPR
  • megator
  • NPC-associated intranuclear protein
In more languages
default for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
10 references
retrieved
8 April 2019
stated in
Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
The subcellular distribution and function of MTA1 in cancer differentiation
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polyglutamine expansion of huntingtin impairs its nuclear export
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IPI
cell component
nuclear membrane
determination method or standard
IDA
IEA
14 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IEA
retrieved
8 April 2019
stated in
Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
nuclear periphery
determination method or standard
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IEA
retrieved
8 April 2019
stated in
The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
nuclear pore
determination method or standard
IDA
IEA
7 references
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12270&geneProductId=UniProtKB:P12270
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12270&geneProductId=UniProtKB:P12270
determination method or standard
IEA
retrieved
26 September 2017
stated in
Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12270&geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
26 September 2017
stated in
Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12270&geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
26 September 2017
stated in
Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12270&geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
26 September 2017
stated in
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12270&geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
26 September 2017
stated in
Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12270&geneProductId=UniProtKB:P12270
determination method or standard
IDA
nuclear pore nuclear basket
determination method or standard
IDA
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IEA
retrieved
8 April 2019
stated in
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
nuclear pore
determination method or standard
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IEA
retrieved
8 April 2019
stated in
Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IBA
biological process
protein import into nucleus
determination method or standard
IDA
TAS
IMP
4 references
retrieved
8 April 2019
stated in
Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
TAS
retrieved
8 April 2019
stated in
Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IMP
retrieved
8 April 2019
stated in
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IMP
retrieved
8 April 2019
stated in
Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export
GOA
curator
UniProt
UniProt protein ID
P12270
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12270
determination method or standard
IDA

Identifiers

Freebase ID
/m/02rwn6_
0 references
 
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