(Q21119274)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13473

transporter of unknown biochemical mechanism

1 reference

Transporter Classification Database ID

9.A.16.1.2

hierarchical database ID heuristic

2 October 2019

based on heuristic

Lysosome-associated membrane glycoprotein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

LAMP2.png
1,920 × 975; 533 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

protein domain specific binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

protein binding

1 reference

9 May 2019

Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

enzyme binding

1 reference

9 May 2019

The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

1 reference

9 May 2019

membrane microdomain

1 reference

9 May 2019

Chaperone-mediated autophagy: molecular mechanisms and physiological relevance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

phagocytic vesicle membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

chaperone-mediated autophagy translocation complex

1 reference

26 September 2017

A receptor for the selective uptake and degradation of proteins by lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

9 May 2019

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

lysosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

5 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

26 September 2017

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

26 September 2017

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

26 September 2017

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

lysosomal lumen

1 reference

9 May 2019

Chaperone-mediated autophagy: molecular mechanisms and physiological relevance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

lysosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

6 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

The lysosomal protein cathepsin L is a progranulin protease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

1 reference

9 May 2019

extracellular exosome

4 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

26 September 2017

Exosomal-like vesicles are present in human blood plasma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

autophagosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

1 reference

9 May 2019

extracellular space

1 reference

9 May 2019

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

trans-Golgi network

1 reference

26 September 2017

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

1 reference

9 May 2019

azurophil granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

1 reference

9 May 2019

autolysosome

1 reference

9 May 2019

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

perinuclear region of cytoplasm

1 reference

26 September 2017

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

integral component of autophagosome membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

ficolin-1-rich granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

1 reference

9 May 2019

lysosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

8 April 2019

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

8 April 2019

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

8 April 2019

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

membrane raft

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

extracellular exosome

Exosomal-like vesicles are present in human blood plasma

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

lysosomal matrix

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

lysosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

6 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

late endosome membrane

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

regulation of protein stability

biological process

1 reference

9 May 2019

Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

muscle cell cellular homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

platelet degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

1 reference

9 May 2019

protein import

1 reference

9 May 2019

Chaperone-mediated autophagy: molecular mechanisms and physiological relevance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

negative regulation of protein homooligomerization

1 reference

26 September 2017

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13473&geneProductId=UniProtKB:P13473

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

1 reference

9 May 2019

chaperone-mediated autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

4 references

9 May 2019

ISS

9 May 2019

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Degradation of AF1Q by chaperone-mediated autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

protein targeting to lysosome involved in chaperone-mediated autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

3 references

8 April 2019

ISS

8 April 2019

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

lysosomal protein catabolic process

1 reference

9 May 2019

Degradation of AF1Q by chaperone-mediated autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

cellular response to starvation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

protein targeting to lysosome involved in chaperone-mediated autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

4 references

9 May 2019

ISS

9 May 2019

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

establishment of protein localization to organelle

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

autophagosome maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13473

lysosome-associated membrane glycoprotein, conserved site

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13473

Identifiers

MeSH descriptor ID

D052119

subject named as

Lysosomal-Associated Membrane Protein 2

0 references

MeSH tree code

D12.776.395.550.550.750

0 references

D12.776.543.550.527.750

0 references

D09.400.430.890.550.750

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

English

Transporter Classification Database ID

9.A.16.1.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023