(Q21116529)

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Winged helix-like DNA-binding domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Dbl homology (DH) domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

PDZ superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

PH-like domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

pleckstrin homology domain, protein family

1 reference

PDZ domain, protein family

1 reference

DEP domain, protein family

1 reference

Dbl homology (DH) domain, protein family

1 reference

Guanine-nucleotide dissociation stimulator, CDC24, conserved site, protein family

1 reference

GTPase activator activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

3 references

8 April 2019

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

1 reference

8 April 2019

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

guanyl-nucleotide exchange factor activity

IDA

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

3 references

5 June 2018

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

4 references

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

intracellular signal transduction

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

neutrophil activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

regulation of dendrite development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

neutrophil chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

reactive oxygen species metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

regulation of actin filament polymerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

actin filament polymerization

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

positive regulation of GTPase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

positive regulation of substrate adhesion-dependent cell spreading

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

regulation of Rho protein signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

superoxide metabolic process

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

positive regulation of cell adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

negative regulation of protein kinase activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

positive regulation of cell migration

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

negative regulation of TOR signaling

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

positive regulation of apoptotic process

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

regulation of small GTPase mediated signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

G protein-coupled receptor signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Dbl homology (DH) domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

pleckstrin homology domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Guanine-nucleotide dissociation stimulator, CDC24, conserved site

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

DEP domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016