Wikidata

(Q21112289)

English

Nuclear receptor subfamily 1 group H member 3

mammalian protein found in Homo sapiens

  • Liver X receptor alpha
  • liver X nuclear receptor alpha variant 1
  • NR1H3
  • oxysterols receptor LXR-alpha
In more languages
default for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
11 references
retrieved
8 April 2019
stated in
GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
GOA
curator
UniProt
UniProt protein ID
Q13133
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase
GOA
curator
UniProt
UniProt protein ID
Q13133
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
GOA
curator
UniProt
UniProt protein ID
Q13133
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
GOA
curator
UniProt
UniProt protein ID
Q13133
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular determinants of the interactions between SRC‐1 and LXR/RXR heterodimers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Y2H-seq approach defines the human protein methyltransferase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IPI
cell component
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IDA
IMP
7 references
retrieved
24 April 2018
stated in
Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133
determination method or standard
IMP
retrieved
24 April 2018
stated in
FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133
determination method or standard
IMP
retrieved
24 April 2018
stated in
GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
GOA
curator
UniProt
UniProt protein ID
Q13133
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
24 April 2018
stated in
Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
GOA
curator
UniProt
UniProt protein ID
Q13133
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
24 April 2018
stated in
The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
24 April 2018
stated in
Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
24 April 2018
stated in
Regulation of LPCAT3 by LXR
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133
determination method or standard
IDA
positive regulation of transcription by RNA polymerase II
determination method or standard
IBA
IDA
IMP
8 references
retrieved
8 April 2019
stated in
Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IMP
retrieved
8 April 2019
stated in
FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IMP
retrieved
8 April 2019
stated in
GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
GOA
curator
UniProt
UniProt protein ID
Q13133
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
8 April 2019
stated in
Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
GOA
curator
UniProt
UniProt protein ID
Q13133
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
8 April 2019
stated in
Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
8 April 2019
stated in
The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
8 April 2019
stated in
Regulation of LPCAT3 by LXR
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133
determination method or standard
IBA

Identifiers

RefSeq protein ID
Ensembl protein ID
 
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