(Q21105158)

http://www.ebi.ac.uk/interpro/protein/Q14185

SH3-like domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q14185

Dedicator of cytokinesis protein 1

1 reference

http://www.ebi.ac.uk/interpro/protein/Q14185

Armadillo-type fold

1 reference

http://www.ebi.ac.uk/interpro/protein/Q14185

Dedicator of cytokinesis, N-terminal domain, protein family

1 reference

DHR-1 domain, protein family

1 reference

DHR-2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

guanyl-nucleotide exchange factor activity

1 reference

13 November 2019

1 reference

13 November 2019

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

8 references

1 January 2018

An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

A human MAP kinase interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

PH domain of ELMO functions in trans to regulate Rac activation via Dock180

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

guanyl-nucleotide exchange factor complex

IEA

1 reference

1 January 2018

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

3 references

1 January 2018

Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by fluorescence in situ hybridization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 January 2018

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

Fc-gamma receptor signaling pathway involved in phagocytosis

IDA

biological process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

phagocytosis, engulfment

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

vascular endothelial growth factor receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

cytoskeleton organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

integrin-mediated signaling pathway

IEA

1 reference

1 January 2018

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

1 reference

1 January 2018

Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by fluorescence in situ hybridization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

positive regulation of GTPase activity

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

positive regulation of epithelial cell migration

IEA

1 reference

1 January 2018

DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185

positive regulation of substrate adhesion-dependent cell spreading

IMP

1 reference

1 January 2018

DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14185