(Q14916272)

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000234906/MONDO_0008810

based on heuristic

inferred from an Open Targets association score over 0.7

chromosome

human chromosome 19

genomic assembly

1 reference

1 reference

45445495

1 reference

45449243

1 reference

44946035

1 reference

45452822

1 reference

44949565

enzyme activator activity

1 reference

19q13.32

1 reference

15 May 2022

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

1 reference

18 July 2017

lipid binding

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

phospholipase activator activity

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

protein homodimerization activity

1 reference

18 July 2017

Identification of disulfide-linked apolipoprotein species in human lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

phospholipase binding

IPI

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

lipase inhibitor activity

IPI

1 reference

18 July 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

lipoprotein lipase activator activity

cell component

extracellular region

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

3 references

18 July 2017

18 July 2017

The human plasma proteome: a nonredundant list developed by combination of four separate sources

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

18 July 2017

extracellular space

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

early endosome

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

1 reference

18 July 2017

intermediate-density lipoprotein particle

1 reference

18 July 2017

Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

high-density lipoprotein particle

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

1 reference

18 July 2017

spherical high-density lipoprotein particle

1 reference

18 July 2017

Isolation and characterization of human apolipoprotein M-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

chylomicron

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

3 references

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

18 July 2017

18 July 2017

Identification of disulfide-linked apolipoprotein species in human lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

extracellular exosome

1 reference

18 July 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

retinoid metabolic process

biological process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

1 reference

18 July 2017

transport

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

1 reference

18 July 2017

positive regulation of phospholipase activity

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

positive regulation of triglyceride catabolic process

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

positive regulation of very-low-density lipoprotein particle remodeling

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

negative regulation of very-low-density lipoprotein particle clearance

1 reference

18 July 2017

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

lipid catabolic process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

1 reference

18 July 2017

negative regulation of cholesterol transport

1 reference

18 July 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

cholesterol efflux

1 reference

18 July 2017

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

phospholipid efflux

1 reference

18 July 2017

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

triglyceride-rich lipoprotein particle remodeling

1 reference

18 July 2017

Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

very-low-density lipoprotein particle remodeling

1 reference

18 July 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

high-density lipoprotein particle remodeling

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

1 reference

18 July 2017

chylomicron assembly

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

1 reference

18 July 2017

chylomicron remnant clearance

1 reference

18 July 2017

Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

high-density lipoprotein particle clearance

1 reference

18 July 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

cholesterol homeostasis

1 reference

18 July 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

lipoprotein transport

Ensembl genome database project

1 reference

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

negative regulation of catalytic activity

1 reference

18 July 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

reverse cholesterol transport

1 reference

18 July 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

positive regulation of fatty acid biosynthetic process

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

negative regulation of lipid metabolic process

1 reference

18 July 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

negative regulation of receptor-mediated endocytosis

1 reference

18 July 2017

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

positive regulation of lipoprotein lipase activity

positive regulation of phospholipid catabolic process

1 reference

18 July 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

triglyceride homeostasis

1 reference

18 July 2017

Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02655

https://www.bgee.org/gene/ENSG00000234906

HomoloGene ID

47928

1 reference

15 May 2022

1 reference

47928

1 reference

47928

1

1 reference

7 June 2024

substantia nigra

https://www.bgee.org/gene/ENSG00000234906

2

1 reference

7 June 2024

C1 segment

https://www.bgee.org/gene/ENSG00000234906

3

1 reference

7 June 2024

duodenum

https://www.bgee.org/gene/ENSG00000234906

4

1 reference

7 June 2024

caudate nucleus

https://www.bgee.org/gene/ENSG00000234906

5

1 reference

7 June 2024

putamen

https://www.bgee.org/gene/ENSG00000234906

6

1 reference

7 June 2024

amygdala

https://www.bgee.org/gene/ENSG00000234906

7

1 reference

7 June 2024

testicle

https://www.bgee.org/gene/ENSG00000234906

8

1 reference

7 June 2024

nucleus accumbens

https://www.bgee.org/gene/ENSG00000234906

9

1 reference

7 June 2024

hypothalamus

https://www.bgee.org/gene/ENSG00000234906

10

1 reference

7 June 2024

exact match

http://identifiers.org/ncbigene/344

1 reference

Identifiers.org

http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069

Identifiers

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

Ensembl transcript ID

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

1 reference

15 May 2022

1 reference

15 May 2022

Microsoft Academic ID

0 references

2 references

Online Mendelian Inheritance in Man

19 August 2019

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

UMLS CUI

C1412477

1 reference

based on heuristic

inferred by common HGNC mappings on source and on Wikidata

UMLS 2023