Wikidata

(Q14907340)

English

Spleen tyrosine kinase

mammalian protein found in Mus musculus

  • Syk
  • tyrosine-protein kinase SYK
In more languages
default for all languages
No label defined

No description defined

Statements

part of
molecular function
protein binding
determination method or standard
IPI
12 references
retrieved
9 May 2019
stated in
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
retrieved
9 May 2019
stated in
Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IPI
protein tyrosine kinase activity
determination method or standard
IDA
IEA
IMP
ISO
10 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
ISO
retrieved
9 May 2019
stated in
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IEA
retrieved
9 May 2019
stated in
TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
9 May 2019
stated in
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
9 May 2019
stated in
Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
9 May 2019
stated in
Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
9 May 2019
stated in
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
9 May 2019
stated in
Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
protein tyrosine kinase activity
determination method or standard
EXP
IDA
IEA
IMP
ISO
11 references
retrieved
1 January 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
ISO
retrieved
1 January 2018
stated in
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IEA
retrieved
1 January 2018
stated in
Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
1 January 2018
stated in
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
1 January 2018
stated in
TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
1 January 2018
stated in
Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
1 January 2018
stated in
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
1 January 2018
stated in
Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
1 January 2018
stated in
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025
determination method or standard
EXP
cell component
biological process
peptidyl-tyrosine phosphorylation
determination method or standard
IDA
IMP
5 references
retrieved
9 May 2019
stated in
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI
GOA
curator
UniProt
UniProt protein ID
P48025
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IMP
retrieved
9 May 2019
stated in
Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
9 May 2019
stated in
Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
9 May 2019
stated in
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA
retrieved
9 May 2019
stated in
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025
determination method or standard
IDA

Identifiers

 
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