Wikidata

(Q14907088)

English

Runt related transcription factor 2

mammalian protein found in Mus musculus

  • runt domain, alpha subunit 1
  • PEA2-alpha A
  • PEBP2 alpha A
  • Runx2
  • CBF-alpha-1
  • core binding factor alpha 1
  • SL3-3 enhancer factor 1 alpha A subunit
  • transcription factor Cbfa1/Osf2
  • Oncogene AML-3
  • AKV core binding factor
  • Core-binding factor subunit alpha-1
  • SL3/AKV core-binding factor alpha A subunit
  • runt-related transcription factor 2
  • OSF-2
  • acute myeloid leukemia 3 protein
  • PEBP2-alpha A
  • polyomavirus enhancer-binding protein 2 alpha A subunit
  • osteoblast-specific transcription factor 2
In more languages
default for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
14 February 2019
stated in
Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts
GOA
curator
UniProt
UniProt protein ID
Q08775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
retrieved
14 February 2019
stated in
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
ISO
11 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
ISO
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q08775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IEA
retrieved
24 April 2018
stated in
The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing
GOA
curator
UniProt
UniProt protein ID
Q08775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
24 April 2018
stated in
Participation of Runx2 in mandibular condylar cartilage development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
24 April 2018
stated in
SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
24 April 2018
stated in
Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
24 April 2018
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
24 April 2018
stated in
Cbfbeta interacts with Runx2 and has a critical role in bone development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
24 April 2018
stated in
Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISO
12 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q08775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IEA
retrieved
14 February 2019
stated in
The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing
GOA
curator
UniProt
UniProt protein ID
Q08775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Participation of Runx2 in mandibular condylar cartilage development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Cbfbeta interacts with Runx2 and has a critical role in bone development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IBA
biological process
positive regulation of osteoblast differentiation
determination method
IDA
IEA
IGI
ISO
5 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
ISO
retrieved
14 February 2019
stated in
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IGI
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IEA
retrieved
14 February 2019
stated in
Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IDA
IEA
IGI
ISO
16 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
ISO
retrieved
14 February 2019
stated in
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IGI
retrieved
14 February 2019
stated in
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IGI
retrieved
14 February 2019
stated in
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IGI
retrieved
14 February 2019
stated in
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IGI
retrieved
14 February 2019
stated in
Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IGI
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IEA
retrieved
14 February 2019
stated in
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
A twist code determines the onset of osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA
retrieved
14 February 2019
stated in
Cbfbeta interacts with Runx2 and has a critical role in bone development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775
determination method
IDA

Identifiers

 
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