(Q27681830)

1

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Qi Sun

2

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R Nathan Daniels

3

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DeMarco Camper

4

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J Phillip Kennedy

5

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Jason Phan

6

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Edward T Olejniczak

7

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Taekyu Lee

8

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Alex G Waterson

9

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Olivia W Rossanese

10

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Stephen W Fesik

Proceedings of the National Academy of Sciences of the United States of America

11

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publication date

4 March 2014

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published in

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volume

111

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issue

9

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page(s)

3401-6

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cites work

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

1 reference

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

1 reference

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

1 reference

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

1 reference

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

1 reference

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

1 reference

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

1 reference

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

1 reference

Structural analysis of autoinhibition in the Ras activator Son of sevenless

1 reference

Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

1 reference

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

1 reference

The structural basis of the activation of Ras by Sos

1 reference

RAS oncogenes: weaving a tumorigenic web

1 reference