(Q27681830)

1

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Qi Sun

2

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R Nathan Daniels

3

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DeMarco Camper

4

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J Phillip Kennedy

5

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Jason Phan

6

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Edward T Olejniczak

7

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Taekyu Lee

8

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Alex G Waterson

9

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Olivia W Rossanese

Proceedings of the National Academy of Sciences of the United States of America

10

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language of work or name

English

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publication date

4 March 2014

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published in

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volume

111

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issue

9

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page(s)

3401-6

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cites work

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

1 reference

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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

20 March 2017

1 reference

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

20 March 2017

1 reference

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

20 March 2017

1 reference

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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

20 March 2017

1 reference

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Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

20 March 2017

1 reference

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

20 March 2017

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

20 March 2017

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Structural analysis of autoinhibition in the Ras activator Son of sevenless

20 March 2017

1 reference

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Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

20 March 2017

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

20 March 2017

1 reference

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The structural basis of the activation of Ras by Sos

20 March 2017

1 reference

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RAS oncogenes: weaving a tumorigenic web

20 March 2017

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A Ras-induced conformational switch in the Ras activator Son of sevenless

20 March 2017

1 reference

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ras oncogenes in human cancer: a review

20 March 2017

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

7 April 2017

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Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

NMR-based functional profiling of RASopathies and oncogenic RAS mutations.

29 September 2017

1 reference

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Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

29 September 2017

1 reference

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Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

Ras inhibition via direct Ras binding--is there a path forward?

29 September 2017

1 reference

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A comprehensive survey of Ras mutations in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations

29 September 2017

1 reference

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Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

Membrane-dependent signal integration by the Ras activator Son of sevenless

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

Essential role for oncogenic Ras in tumour maintenance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241

Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1315798111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1315798111

1 reference

1 reference

1 reference

PubMed publication ID

24550516

1 reference