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da description scientific article
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ADS bibcode
(P819)
: 2014PNAS..111.3401B,
batch #72370
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(29 intermediate revisions by 13 users not shown)
label / nl
label / nl
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
label / ast
label / ast
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
description / sk
description / sk
vedecký článok (publikovaný 2014/03/04)
description / pt
description / pt
artigo científico (publicado na 2014/03/04)
description / hy
description / hy
2014 թվականի մարտին հրատարակված գիտական հոդված
description / ar
description / ar
مقالة علمية (نشرت في 4-3-2014)
description / pt-br
description / pt-br
artigo científico (publicado na 2014)
description / sr
description / sr
научни чланак
description / hu
description / hu
tudományos cikk
description / tr
description / tr
bilimsel makale
description / tg
description / tg
мақолаи илмӣ
description / ja
description / ja
2014年の論文
description / bn
description / bn
২০১৪-এ প্রকাশিত বৈজ্ঞানিক নিবন্ধ
description / sr-el
description / sr-el
naučni članak
description / el
description / el
επιστημονικό άρθρο
description / sv
description / sv
vetenskaplig artikel
description / gl
description / gl
artigo científico
description / yue
description / yue
2014年論文
description / et
description / et
teaduslik artikkel
description / es
description / es
artículo científico publicado en 2014
description / zh-cn
description / zh-cn
2014年论文
description / zh-my
description / zh-my
2014年论文
description / pl
description / pl
artykuł naukowy
description / zh-hans
description / zh-hans
2014年论文
description / uk
description / uk
наукова стаття, опублікована в березні 2014
description / sq
description / sq
artikull shkencor
description / ast
description / ast
artículu científicu espublizáu en 2014
description / ka
description / ka
სამეცნიერო სტატია
description / nan
description / nan
2014 nî lūn-bûn
description / zh-hant
description / zh-hant
2014年論文
description / zh-mo
description / zh-mo
2014年論文
description / vi
description / vi
bài báo khoa học
description / nb
description / nb
vitenskapelig artikkel
description / tl
description / tl
artikulong pang-agham
description / th
description / th
บทความทางวิทยาศาสตร์
description / nn
description / nn
vitskapeleg artikkel
description / ru
description / ru
научная статья
description / fi
description / fi
tieteellinen artikkeli
description / he
description / he
מאמר מדעי
description / zh-tw
description / zh-tw
2014年論文
description / ca
description / ca
article científic
description / tg-cyrl
description / tg-cyrl
мақолаи илмӣ
description / sr-ec
description / sr-ec
научни чланак
description / zh-hk
description / zh-hk
2014年論文
description / eo
description / eo
scienca artikolo
description / bg
description / bg
научна статия
description / wuu
description / wuu
2014年论文
description / zh
description / zh
2014年论文
description / lt
description / lt
mokslinis straipsnis
description / zh-sg
description / zh-sg
2014年论文
description / ro
description / ro
articol științific
description / oc
description / oc
article scientific
description / ko
description / ko
2014년 논문
description / fa
description / fa
مقالهٔ علمی
description / ur
description / ur
سائنسی مضمون
description / hyw
description / hyw
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
Property /
PubMed publication ID
:
24550516
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stated in
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Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
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1910345
Property /
PMC publication ID
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3948241
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Consolidated OpenCitations Corpus – April 2017
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DOI
10.1073/pnas.1315798111
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DOI
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10.1073/pnas.1315798111
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author name string
Stephen W Fesik
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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
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PubMed Central
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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
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PubMed Central
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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction
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:
PubMed Central
reference URL
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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction
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PubMed Central
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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
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PubMed Central
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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
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PubMed Central
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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
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PubMed Central
reference URL
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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
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PubMed Central
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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
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PubMed Central
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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
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PubMed Central
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Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes
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PubMed Central
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Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes
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PubMed Central
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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
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PubMed Central
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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
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Property /
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
/ reference
stated in
:
PubMed Central
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
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PubMed Central
Property /
cites work
:
Structural analysis of autoinhibition in the Ras activator Son of sevenless
/ reference
stated in
:
PubMed Central
reference URL
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:
Structural analysis of autoinhibition in the Ras activator Son of sevenless
/ reference
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PubMed Central
Property /
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Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism
/ reference
stated in
:
PubMed Central
reference URL
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Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism
/ reference
stated in
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PubMed Central
Property /
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:
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
/ reference
stated in
:
PubMed Central
reference URL
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241
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Property /
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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
/ reference
stated in
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PubMed Central
Property /
cites work
:
The structural basis of the activation of Ras by Sos
/ reference
stated in
:
PubMed Central
reference URL
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:
The structural basis of the activation of Ras by Sos
/ reference
stated in
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PubMed Central
Property /
cites work
RAS oncogenes: weaving a tumorigenic web
Property /
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:
RAS oncogenes: weaving a tumorigenic web
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Normal rank
Property /
cites work
:
RAS oncogenes: weaving a tumorigenic web
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PubMed Central
reference URL
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A Ras-induced conformational switch in the Ras activator Son of sevenless
Property /
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A Ras-induced conformational switch in the Ras activator Son of sevenless
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Normal rank
Property /
cites work
:
A Ras-induced conformational switch in the Ras activator Son of sevenless
/ reference
stated in
:
PubMed Central
reference URL
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ras oncogenes in human cancer: a review
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:
ras oncogenes in human cancer: a review
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Normal rank
Property /
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:
ras oncogenes in human cancer: a review
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PubMed Central
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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Property /
cites work
:
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
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Normal rank
Property /
cites work
:
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
/ reference
stated in
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PubMed Central
reference URL
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Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
Property /
cites work
:
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
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Normal rank
Property /
cites work
:
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
/ reference
stated in
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PubMed Central
reference URL
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NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
Property /
cites work
:
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
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Normal rank
Property /
cites work
:
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
/ reference
stated in
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PubMed Central
reference URL
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Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
Property /
cites work
:
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
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Normal rank
Property /
cites work
:
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
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stated in
:
PubMed Central
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Property /
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Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
Property /
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:
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
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Normal rank
Property /
cites work
:
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
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stated in
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PubMed Central
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Ras inhibition via direct Ras binding--is there a path forward?
Property /
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Ras inhibition via direct Ras binding--is there a path forward?
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Normal rank
Property /
cites work
:
Ras inhibition via direct Ras binding--is there a path forward?
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stated in
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PubMed Central
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29 September 2017
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Property /
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A comprehensive survey of Ras mutations in cancer
Property /
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:
A comprehensive survey of Ras mutations in cancer
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Normal rank
Property /
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:
A comprehensive survey of Ras mutations in cancer
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stated in
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PubMed Central
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Property /
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SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations
Property /
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:
SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations
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Normal rank
Property /
cites work
:
SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations
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stated in
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PubMed Central
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Precision
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Property /
cites work
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation
Property /
cites work
:
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation
/ rank
Normal rank
Property /
cites work
:
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation
/ reference
stated in
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PubMed Central
reference URL
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Precision
1 day
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Property /
cites work
Membrane-dependent signal integration by the Ras activator Son of sevenless
Property /
cites work
:
Membrane-dependent signal integration by the Ras activator Son of sevenless
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Normal rank
Property /
cites work
:
Membrane-dependent signal integration by the Ras activator Son of sevenless
/ reference
stated in
:
PubMed Central
reference URL
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29 September 2017
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Calendar
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Precision
1 day
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After
0
Property /
cites work
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
Property /
cites work
:
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
/ rank
Normal rank
Property /
cites work
:
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
/ reference
stated in
:
PubMed Central
reference URL
:
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241
retrieved
:
29 September 2017
Timestamp
+2017-09-29T00:00:00Z
Timezone
+00:00
Calendar
Gregorian
Precision
1 day
Before
0
After
0
Property /
cites work
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
Property /
cites work
:
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
/ rank
Normal rank
Property /
cites work
:
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
/ reference
stated in
:
PubMed Central
reference URL
:
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241
retrieved
:
29 September 2017
Timestamp
+2017-09-29T00:00:00Z
Timezone
+00:00
Calendar
Gregorian
Precision
1 day
Before
0
After
0
Property /
cites work
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
Property /
cites work
:
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
/ rank
Normal rank
Property /
cites work
:
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
/ reference
stated in
:
PubMed Central
reference URL
:
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241
retrieved
:
29 September 2017
Timestamp
+2017-09-29T00:00:00Z
Timezone
+00:00
Calendar
Gregorian
Precision
1 day
Before
0
After
0
Property /
cites work
Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway
Property /
cites work
:
Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway
/ rank
Normal rank
Property /
cites work
:
Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway
/ reference
stated in
:
PubMed Central
reference URL
:
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241
retrieved
:
29 September 2017
Timestamp
+2017-09-29T00:00:00Z
Timezone
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Calendar
Gregorian
Precision
1 day
Before
0
After
0
Property /
cites work
Essential role for oncogenic Ras in tumour maintenance
Property /
cites work
:
Essential role for oncogenic Ras in tumour maintenance
/ rank
Normal rank
Property /
cites work
:
Essential role for oncogenic Ras in tumour maintenance
/ reference
stated in
:
PubMed Central
reference URL
:
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948241
retrieved
:
29 September 2017
Timestamp
+2017-09-29T00:00:00Z
Timezone
+00:00
Calendar
Gregorian
Precision
1 day
Before
0
After
0
Property /
cites work
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
Property /
cites work
:
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
/ rank
Normal rank
Property /
cites work
:
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
/ reference
stated in
:
Crossref
reference URL
:
https://api.crossref.org/works/10.1073%2FPNAS.1315798111
retrieved
:
21 January 2018
Timestamp
+2018-01-21T00:00:00Z
Timezone
+00:00
Calendar
Gregorian
Precision
1 day
Before
0
After
0
Property /
cites work
Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements
Property /
cites work
:
Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements
/ rank
Normal rank
Property /
cites work
:
Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements
/ reference
stated in
:
PubMed
reference URL
:
https://pubmed.ncbi.nlm.nih.gov/24550516
retrieved
:
12 December 2020
Timestamp
+2020-12-12T00:00:00Z
Timezone
+00:00
Calendar
Gregorian
Precision
1 day
Before
0
After
0
based on heuristic
:
inferred from PubMed ID database lookup
Property /
OpenCitations bibliographic resource ID
1910345
Property /
OpenCitations bibliographic resource ID
:
1910345
/ rank
Normal rank
Property /
OpenCitations bibliographic resource ID
:
1910345
/ reference
stated in
:
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
:
1910345
Property /
DOI
10.1073/PNAS.1315798111
Property /
DOI
:
10.1073/PNAS.1315798111
/ rank
Normal rank
Property /
DOI
:
10.1073/PNAS.1315798111
/ reference
stated in
:
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
:
1910345
Property /
ResearchGate publication ID
260253849
Property /
ResearchGate publication ID
:
260253849
/ rank
Normal rank
Property /
language of work or name
English
Property /
language of work or name
:
English
/ rank
Normal rank
Property /
author
Stephen W. Fesik
Property /
author
:
Stephen W. Fesik
/ rank
Normal rank
Property /
author
:
Stephen W. Fesik
/ qualifier
series ordinal
: 11
Property /
author
:
Stephen W. Fesik
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object named as
: Stephen W Fesik
Property /
ADS bibcode
2014PNAS..111.3401B
Property /
ADS bibcode
:
2014PNAS..111.3401B
/ rank
Normal rank