(Q30437441)

21 June 2017

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title

Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy (English)

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21 June 2017

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2

Theresa A Guise

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21 June 2017

Wende Kozlow

1

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21 June 2017

publication date

1 April 2005

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Journal of Mammary Gland Biology and Neoplasia

21 June 2017

published in

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21 June 2017

volume

10

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21 June 2017

issue

2

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21 June 2017

page(s)

169-180

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The clinical course of bone metastases from breast cancer

21 June 2017

cites work

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Bisphosphonates induce apoptosis in human breast cancer cell lines

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Bone cancer pain and the role of RANKL/OPG

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12 December 2020

Breast cancer cells interact with osteoblasts to support osteoclast formation

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Metastasis to bone: causes, consequences and therapeutic opportunities

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12 December 2020

Bisphosphonate risedronate prevents bone loss in women with artificial menopause due to chemotherapy of breast cancer: a double-blind, placebo-controlled study

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases in

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

G protein-coupled extracellular Ca2+ (Ca2+o)-sensing receptor (CaR): roles in cell signaling and control of diverse cellular functions

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bisphosphonates for the prevention of bone metastases

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

The role of bisphosphonates in breast cancer

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Regulation of parathyroid hormone-related protein expression in MCF-7 breast carcinoma cells by estrogen and antiestrogens

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices.

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Cellular and molecular basis of preferential metastasis of breast cancer to bone

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Matrix metalloproteinases in tumor-host cell communication

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

An experimental model of bone metastasis by human lung cancer cells: the role of parathyroid hormone-related protein in bone metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Stromal factors involved in prostate carcinoma metastasis to bone

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Parathyroid hormone related protein and hypercalcaemia in breast cancer

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https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Scanning electron microscopy in bone pathology: review of methods, potential and applications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

TGF-beta signaling: positive and negative effects on tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bone imaging in metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Strategies for MMP inhibition in cancer: innovations for the post-trial era.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bone marrow micrometastasis in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bone secondaries in breast cancer: the solitary metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

A multigenic program mediating breast cancer metastasis to bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Parathyroid hormone related protein and skeletal morbidity in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Chemotactic Responses of Tumor Cells to Products of Resorbing Bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Molecular mechanisms of cancer pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Integrin activation controls metastasis in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Optimizing bisphosphonate therapy in patients with breast cancer on endocrine therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Molecular mechanisms of osteolytic bone metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

The distribution of secondary growths in cancer of the breast. 1889

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bone metabolic markers as gauges of metastasis to bone: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

The role of the alphaVbeta3 integrin in the development of osteolytic bone metastases: a pharmacological target for alternative therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Pharmacological regulation of parathyroid hormone secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bisphosphonates and the prevention of metastasis: first evidences from preclinical and clinical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

The microenvironment of the tumour-host interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Localization of parathyroid hormone-related protein mRNA expression in breast cancer and metastatic lesions by in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Involvement of chemokine receptors in breast cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Toward new horizons: the future of bisphosphonate therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

A murine model of experimental metastasis to bone and bone marrow.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Parathyroid hormone-related protein purified from a human lung cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/16025223

1 reference

12 December 2020

Bone metastases in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Metastatic breast cancer confined to the skeletal system. An indolent disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Hormone- and chemotherapy-induced bone loss in breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Histomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bone destruction and hypercalcemia in plasma cell myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

A role for curative surgery in the treatment of selected patients with metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Markers of bone turnover in bone metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Current and future status of adjuvant therapy for breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bone sialoprotein peptides are potent inhibitors of breast cancer cell adhesion to bone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Calcium stimulates parathyroid hormone-related protein production in Leydig tumor cells through a putative cation-sensing mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bisphosphonates: clinical experience

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Parathyroid hormone-related protein production by breast cancers, improved survival, and reduced bone metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Treatment of metastatic bone disease in breast cancer: bisphosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

The skeleton as a unique environment for breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Endothelin and the tumorigenic component of bone cancer pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Breast cancer metastasis to bone: it is not all about PTHrP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Bisphosphonates induce breast cancer cell death in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Cachexia in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

Markers of bone turnover for the management of patients with bone metastases from prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025223

12 December 2020

10.1007/S10911-005-5399-8

Identifiers

DOI

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21 June 2017

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