John Marston (voice)
John 'Jack' Marston Jr. (voice)
Abigail Marston (voice)
Uncle (voice)
Dutch van der Linde / Nastas (voice)
Bonnie MacFarlane (voice)
Drew MacFarlane (voice)
Marshal Leigh Johnson (voice)
Deputy Marshal 1 (Jonah) (voice)
Deputy Marshal 2 (Eli) (voice)
Norman Deek (voice)
Nigel West Dickens (voice)
Professor Harold MacDougal / Government Clerk (voice)
Seth Briars (voice)
Welsh (Alwyn Lloyd) (voice)
French (Leander Holland) (voice)
Irish / Various (voice) (as Kharrison Sweeny)
Bill Williamson (voice)
Captain Vincente De Santa (voice)
Landon Ricketts (voice)
Andreas Müller (voice)
Colonel Agustin Allende (voice)
Abraham Reyes (voice)
Luisa Fortuna (voice)
Miranda Fortuna (voice)
Luisa's Mother (voice)
Emilio Fortuna / The Local Population (voice)
Luisa's Father (voice)
Javier Escuella (voice)
Edgar Ross (voice)
Archer Fordham (voice)
Mrs. Ditkiss (voice)
Mrs. Bush (voice)
Preacher (voice)
Jenny (voice)
Paperboy / The Local Population (voice)
Jake (voice)
Simon (voice)
Amos (voice)
Pretty Waiter (voice) (as Alex Estornel)
Moses Forth (voice)
Shaky (voice)
Carlos / Bank (voice)
Captain Espinoza (voice)
Outlaw on Horse (voice) (as Brian Allen)
Honeymoon Woman / The Local Population (voice)
Honeymoon Man (voice)
Mexican Army Officer (voice)
Uriah Tollets / Harold Thornton / Stanley Palmer (voice)
Eva Cortes (voice)
Sam Odessa / Drunk Man (voice)
Charles Kinnear / Bureau Agent (Howard Sawicki) (voice)
Strange Man / The Local Population (voice)
Basilio Aguirre Olmos de la Vargas / Mexican Revolutionary (voice)
Jimmy Saint (voice) (as Paul De Boy)
Cannibal (Randal Forrester) (voice)
Oliver Philips / Aldous Worthington (voice)
Phillip Ross (voice)
Fiddler (Nathan Harling) (voice) (as Wayne Alan Wilcox)
Fiddler's Wife (Rose Harling) (voice)
Andrew McAllister (voice)
Nun (voice)
D.S. MacKenna / Mr. Philmore (voice)
Billy West (voice)
Zhou (voice)
Desperate Woman / Emily Ross (voice)
Jeb Blankenship (voice) (as Bryan Shany)
Mario Alcalde (voice) (as Juan Carlos Hernandez)
Miss Horlick (voice)
Elizabeth Thornton (voice)
Silas Spatchcock (voice)
Clara LaGuerta (voice) (as Ashley Albert)
Andrew Holifield (voice)
Clyde Evans (voice) (as Bruce MacVitte)
Foreman (Juan de la Vara) (voice)
Walton Lowe (voice) (as PJ Sosko)
Aquila (voice)
Multiplayer Narrator / The Local Population (voice)
The Local Population (voice)
The Local Population (voice) (as Abdel Gonzáles)
The Local Population (voice) (as AnQuoc Hoang)
The Local Population (voice) (as Calvin 'CalKutta' Winbush II)
The Local Population (voice) (as Carlos East)
The Local Population (voice) (as Carlos Andres Gómez)
Vernon Cherry / The Local Population (voice)
The Local Population (voice) (as Chookie Sibou)
The Local Population (voice) (as Corey Carthew)
The Local Population (voice) (as Daniel Taylor)
The Local Population (voice) (as Deric McGee Jr.)
The Local Population (voice) (as Doctah-Daiv)
The Local Population (voice) (as Elsa Morales)
Katie (voice)
The Local Population (voice) (as Enrique Julia)
The Local Population (voice) (as Esteban Penz)
The Local Population (voice) (as Fidel)
The Local Population (voice) (as Floyd VanBuskirk)
The Local Population (voice) (as Forest Karbowski)
Pharmacist (voice)
The Local Population (voice) (as Gary Chan)
The Local Population (voice) (as George T. Irvin Jr.)
The Local Population (voice) (as Giselle Castellanos)
Merche Coronado (voice)
The Local Population (voice) (as Gregory Johnson)
Raul Zubieta - Mexican Lawman (voice) (as Hector Ruiz)
Mexican Law Man (voice)
Oscar Farley (voice)
Benjamin Dupuis (voice)
Mexican Captain / The Local Population (voice)
Cowboy (voice)
Corrupt Sheriff (voice)
The Local Population (voice) (as Jonathan Seymour)
Hinto (voice)
Mexican Miner (voice) (as Jose De Vega)
Victor Melendez (voice) (as Julian Dean)
Floyd Brogles (voice)
The Local Population (voice) (as KT Peterson)
The Local Population (voice) (as Kyle C. McDuffie)
The Local Population (voice) (as LaToya Lewis)
Lawman (voice)
The Local Population (voice) (as Lloyd Knight)
Porfirio Gutierrez (voice)
Prostitute (voice)
The Local Population (voice) (as Marco Peláez)
The Local Population (voice) (as Marco S. Rodriguez)
The Local Population (voice) (as Marissa Palumbo)
Mexican Lawman (voice) (as Massimiliano Fulan)
The Local Population (voice) (as Matt Damhave)
Morgan Sterling (voice) (as Matthew P. McCarthy)
Multiple (voice) (as Max Williams)
Ralph Stricker (voice)
The Local Population (voice) (as Modesto Lacén)
The Local Population (voice) (as Noe Ramierz)
The Local Population (voice) (as Oskar Rodríguez)
Local Population (voice)
Pedestrian / Background Character (voice)
The Local Population (voice) (as Phillip Watt)
The Local Population (voice) (as Priscilla López)
Rigoberto Artiz / The Local Population (voice)
Outlaw (voice)
The Local Population (voice) (as Rick Negrón)
The Local Population (voice) (as Robbie Collier Sublett)
The Local Population (voice) (as Roberto Fabiani)
Guy Crossfield (voice)
The Local Population (voice) (as Russell Forman)
The Local Population (voice) (as Samson A. Crouppen)
The Local Population (voice) (as Ted O'Brien)
The Local Population (voice) (as Terrence McCrossan)
Benton Manning (voice)
Lewis Pickering (voice)
The Local Population (voice) (as Trinidad Zues Nizelli)
The General (voice)
The Local Population (voice) (as Walter Emanuel Jones)
The Local Population (voice) (as Wendoliza)
The Local Population (voice) (as Yorke G. Fryer)
Sister Calderón (voice)
Bert Venter (voice)
Red Harlow (voice) (uncredited)
Additional Voices (voice) (uncredited)
Girl Fighter (voice) (uncredited)
Pedestrian / Background Character (voice) (uncredited)
Mexican Girl (voice) (uncredited)
Various (voice) (uncredited)
Jeb Murphy / Herbert Moon (voice) (uncredited)
Blacksmith (voice) (uncredited)
Ugly Chris Bailey (voice) (uncredited)
Buffalo Soldier (voice) (uncredited)
Various Characters (voice) (uncredited)
Shadow Wolf (voice) (uncredited)
Annie Stoakes (voice) (uncredited)
Jack Swift (voice) (uncredited)
Mr. Kelley (voice) (uncredited)
Cristo Bustamante (voice) (uncredited)
Clay Pettiford (voice) (uncredited)
Pig Josh (voice) (uncredited)
Luz / Mexican Woman (voice) (uncredited)
Alvin Briggs (voice) (uncredited)
Angry Farmhouse Woman (voice) (uncredited)