- Dubbed the voice of ailing David Niven for Curse of the Pink Panther (1983).
- Comedian and celebrity impressionist. Among his many comic impressions have included fellow comedians (e.g., Johnny Carson and Robin Williams), movie stars (Jack Nicholson, Vincent Price, Sylvester Stallone, Jimmy Stewart and John Wayne), fictional TV characters (Big Bird and Edith Bunker) and every U.S. President since John F. Kennedy (and their major challengers, including Ross Perot and Senator Bob Dole).
- His wife, Jeanne Worden, was Joey Bishop's secretary.
- Was cast by Orson Welles as the character Otterlake in his autobiographical film The Other Side of the Wind (2018), which co-starred Welles himself and fellow director-actor John Huston. Welles praised Little's acting, saying that impressionists seemed to make good actors. However, Little had to drop out of the movie since Welles improvisational style of filming, as well as layoffs caused by budgetary constraints, meant that the shooting schedule was not only unpredictable but practically interminable. When Little was unavailable for filming due to his honoring prior commitments, Welles replaced him with director Peter Bogdanovich, in whose house Welles was then living. The film was never completed during Welles' lifetime.
- Active in several charities benefiting children, including the Juvenile Diabetes Fund and the Children's Miracle Network.
- Became a naturalized United States citizen in Las Vegas, Nevada where he was residing (2010).
- He was awarded a Star on the Hollywood Walk of Fame for Television at 6372 Hollywood Boulevard in Hollywood, California on July 27, 1983.
- Has been inducted into the Miami Children's Hospital International Pediatrics Hall of Fame.
- Was a regular on the "Dean Martin Celebrity Roasts".
- Dubbed James Cagney's voice in the television movie Terrible Joe Moran (1984). Cagney was not able to properly articulate his lines, during shooting, due to the effects of a stroke.
- Long time manager Perry Potkin embezzled money for years from Mr. Little before he was caught.
- Portrayed President Richard Nixon more than any other actor in live action features.
- Achieved the rank of Queen's Scout in the Boy Scouts of Canada.
- Had the honor of hosting the 2007 White House Correspondents' Association Dinner on April 21, 2007. The dinner has been held each year since 1920 and often is attended by the President of the United States and other powerful figures in government, as well as members of the press and celebrities. President George W. Bush attended the 2007 dinner, which in addition to Little, featured David Letterman doing a "Top 10 George W. Bush Moments" shtick. ABC News anchorman Charles Gibson, former CBS News anchorman Bob Schieffer, and George Stephanopoulus of ABC News were among the members of the press attending the dinner, while the politicos in attendance included current and former New York Mayors Michael Bloomberg and Rudy Giuliani. The celebrities in attendance included Olympic figure skater Michelle Kwan, American Idol (2002) contestant Sanjaya Malakar, two-time Oscar winner Jane Fonda, and television stars Teri Hatcher, Bill Paxton and Larry David. Secretary of State Condoleezza Rice also was in attendance. Schieffer lauded Little's Master of Ceremonies performance, commenting "I thought he was great. Generally old-fashioned kind of humor but funny.".
- Had a love child with a baccarat dealer in Reno, Nevada. This is what led to his divorce from his first wife.
- He was awarded a Golden Palm Star on the Palm Springs Walk of Stars in Palm Springs, California on November 14, 1998.
- He was awarded a star on Canada's Walk of Fame in Toronto, Ontario in 1998.
- He was awarded a star on the Las Vegas Walk of Stars in Las Vegas, Nevada on February 15, 2005.
- He was awarded the O.C. (Officer of the Order of Canada) on November 9, 2022 from the Canadian Governor General. He lives in Las Vegas, Nevada, United States of America.
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