- He was the first Celebrity Jeopardy Champion.
- His father is a 30-year veteran of the LAPD.
- Hated golf until he co-starred in Tin Cup (1996) ; now is an avid golfer.
- He is of Mexican descent, and is among the top collectors of Mexican and Mexican-American art, having put together at least one book on the subject, and supported the development of Chicano art on the West Coast.
- "Cheech" is derived from chicharron, a spicy fried pork skin snack.
- Has worked with director Robert Rodriguez eight times, starting with Desperado (1995), From Dusk Till Dawn (1996), Spy Kids (2001), Spy Kids 2: Island of Lost Dreams (2002), Once Upon a Time in Mexico (2003), Spy Kids 3: Game Over (2003), Grindhouse (2007), and Machete (2010).
- Owns and plays Taylor guitars.
- Played in the 2005 All-Star Cup golf tournament, dubbed the 'Celebrity Ryder Cup', at Newport, Wales, UK.
- Majored in English at Calfornia State University Northridge.
- Serves as a board member for the Hispanic Scholarship Fund.
- Resides in San Francisco's Seacliff neighborhood
- Is a brother of Phi Sigma Kappa fraternity
- Wife Natasha Rubin is a classical pianist.
- Awarded 'Best Supporting Actor' for Dark Harvest (2016) at the 2016 New York City Cannabis Film Festival.
- Speaks fluent Spanish.
- He and Tommy Chong together comprise the comedy duo Cheech & Chong.
- Biography in: "Who's Who in Comedy" by Ronald L. Smith. Pg. 104-105 (article "Cheech and Chong"). New York: Facts on File, 1992. ISBN 0816023387
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