Online-Ressource | |
Verfasst von: | Kalinichenko, Liubov [VerfasserIn] |
Mühle, Christiane [VerfasserIn] | |
Jia, Tianye [VerfasserIn] | |
Anderheiden, Felix [VerfasserIn] | |
Datz, Maria [VerfasserIn] | |
Eberle, Anna-Lisa [VerfasserIn] | |
Eulenburg, Volker [VerfasserIn] | |
Granzow, Jonas [VerfasserIn] | |
Hofer, Martin [VerfasserIn] | |
Hohenschild, Julia [VerfasserIn] | |
Huber, Sabine E [VerfasserIn] | |
Kämpf, Stefanie [VerfasserIn] | |
Kogias, Georgios [VerfasserIn] | |
Lacatusu, Laura [VerfasserIn] | |
Lugmair, Charlotte [VerfasserIn] | |
Taku, Stephen Mbu [VerfasserIn] | |
Meixner, Doris [VerfasserIn] | |
Sembritzki, Nina-Kristin [VerfasserIn] | |
Praetner, Marc [VerfasserIn] | |
Rhein, Cosima [VerfasserIn] | |
Sauer, Christina [VerfasserIn] | |
Scholz, Jessica [VerfasserIn] | |
Ulrich, Franziska [VerfasserIn] | |
Valenta, Florian [VerfasserIn] | |
Weigand, Esther [VerfasserIn] | |
Werner, Markus [VerfasserIn] | |
Tay, Nicole [VerfasserIn] | |
Mc Veigh, Conor J [VerfasserIn] | |
Haase, Jana [VerfasserIn] | |
Wang, An-Li [VerfasserIn] | |
Abdel-Hafiz, Laila [VerfasserIn] | |
Huston, Joseph P [VerfasserIn] | |
Smaga, Irena [VerfasserIn] | |
Frankowska, Malgorzata [VerfasserIn] | |
Filip, Malgorzata [VerfasserIn] | |
Lourdusamy, Anbarasu [VerfasserIn] | |
Kirchner, Philipp [VerfasserIn] | |
Ekici, Arif B [VerfasserIn] | |
Marx, Lena M [VerfasserIn] | |
Suresh, Neeraja Puliparambil [VerfasserIn] | |
Frischknecht, Renato [VerfasserIn] | |
Fejtova, Anna [VerfasserIn] | |
Saied, Essa M [VerfasserIn] | |
Arenz, Christoph [VerfasserIn] | |
Bozec, Aline [VerfasserIn] | |
Wank, Isabel [VerfasserIn] | |
Kreitz, Silke [VerfasserIn] | |
Hess, Andreas [VerfasserIn] | |
Bäuerle, Tobias [VerfasserIn] | |
Ledesma, Maria Dolores [VerfasserIn] | |
Mitroi, Daniel N [VerfasserIn] | |
Miranda, André M [VerfasserIn] | |
Oliveira, Tiago Gil [VerfasserIn] | |
Lenz, Bernd [VerfasserIn] | |
Schumann, Gunter [VerfasserIn] | |
Kornhuber, Johannes [VerfasserIn] | |
Müller, Christian P [VerfasserIn] | |
Titel: | Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males |
Verf.angabe: | Liubov S. Kalinichenko, Christiane Mühle, Tianye Jia, Felix Anderheiden, Maria Datz, Anna-Lisa Eberle, Volker Eulenburg, Jonas Granzow, Martin Hofer, Julia Hohenschild, Sabine E. Huber, Stefanie Kämpf, Georgios Kogias, Laura Lacatusu, Charlotte Lugmair, Stephen Mbu Taku, Doris Meixner, Nina-Kristin Sembritzki, Marc Praetner, Cosima Rhein, Christina Sauer, Jessica Scholz, Franziska Ulrich, Florian Valenta, Esther Weigand, Markus Werner, Nicole Tay, Conor J. Mc Veigh, Jana Haase, An-Li Wang, Laila Abdel-Hafiz, Joseph P. Huston, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Anbarasu Lourdusamy, Philipp Kirchner, Arif B. Ekici, Lena M. Marx, Neeraja Puliparambil Suresh, Renato Frischknecht, Anna Fejtova, Essa M. Saied, Christoph Arenz, Aline Bozec, Isabel Wank, Silke Kreitz, Andreas Hess, Tobias Bäuerle, Maria Dolores Ledesma, Daniel N. Mitroi, André M. Miranda, Tiago Gil Oliveira, Bernd Lenz, Gunter Schumann, Johannes Kornhuber, Christian P. Müller |
E-Jahr: | 2023 |
Jahr: | 1 February 2023 |
Umfang: | 21 S. |
Fussnoten: | Online veröffentlicht: 16. März 2022 ; Gesehen am 01.07.2024 |
Titel Quelle: | Enthalten in: Cerebral cortex |
Ort Quelle: | Oxford : Oxford Univ. Press, 1991 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 33(2023), 3 vom: Feb., Seite 844-864 |
ISSN Quelle: | 1460-2199 |
Abstract: | Alcohol use, abuse, and addiction, and resulting health hazards are highly sex-dependent with unknown mechanisms. Previously, strong links between the SMPD3 gene and its coded protein neutral sphingomyelinase 2 (NSM) and alcohol abuse, emotional behavior, and bone defects were discovered and multiple mechanisms were identified for females. Here we report strong sex-dimorphisms for central, but not for peripheral mechanisms of NSM action in mouse models. Reduced NSM activity resulted in enhanced alcohol consumption in males, but delayed conditioned rewarding effects. It enhanced the acute dopamine response to alcohol, but decreased monoaminergic systems adaptations to chronic alcohol. Reduced NSM activity increased depression- and anxiety-like behavior, but was not involved in alcohol use for the self-management of the emotional state. Constitutively reduced NSM activity impaired structural development in the brain and enhanced lipidomic sensitivity to chronic alcohol. While the central effects were mostly opposite to NSM function in females, similar roles in bone-mediated osteocalcin release and its effects on alcohol drinking and emotional behavior were observed. These findings support the view that the NSM and multiple downstream mechanism may be a source of the sex-differences in alcohol use and emotional behavior. |
DOI: | doi:10.1093/cercor/bhac106 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: https://doi.org/10.1093/cercor/bhac106 |
Volltext: https://academic.oup.com/cercor/article/33/3/844/6549689?login=true | |
DOI: https://doi.org/10.1093/cercor/bhac106 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 189278470X |
Verknüpfungen: | → Zeitschrift |