| |  Online-Ressource |
|---|
| Verfasst von: | Friedrich, Mirco [VerfasserIn]  |
|---|
| | Hahn, Markus [VerfasserIn] |
|---|
| | Michel, Julius [VerfasserIn] |
|---|
| | Sankowski, Roman [VerfasserIn] |
|---|
| | Kilian, Michael [VerfasserIn] |
|---|
| | Kehl, Niklas [VerfasserIn] |
|---|
| | Günter, Manina [VerfasserIn] |
|---|
| | Bunse, Theresa [VerfasserIn] |
|---|
| | Pusch, Stefan [VerfasserIn] |
|---|
| | Deimling, Andreas von [VerfasserIn] |
|---|
| | Wick, Wolfgang [VerfasserIn] |
|---|
| | Autenrieth, Stella E. [VerfasserIn] |
|---|
| | Prinz, Marco [VerfasserIn] |
|---|
| | Platten, Michael [VerfasserIn] |
|---|
| | Bunse, Lukas [VerfasserIn] |
|---|
| Titel: | Dysfunctional dendritic cells limit antigen-specific T cell response in glioma |
|---|
| Verf.angabe: | Mirco Friedrich, Markus Hahn, Julius Michel, Roman Sankowski, Michael Kilian, Niklas Kehl, Manina Günter, Theresa Bunse, Stefan Pusch, Andreas von Deimling, Wolfgang Wick, Stella E. Autenrieth, Marco Prinz, Michael Platten, and Lukas Bunse |
|---|
| E-Jahr: | 2023 |
|---|
| Jahr: | February 2023 |
|---|
| Umfang: | 14 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Online veröffentlicht: 24. Mai 2022 ; Gesehen am 24.06.2024 |
|---|
| Titel Quelle: | Enthalten in: Neuro-Oncology |
|---|
| Ort Quelle: | Oxford : Oxford Univ. Press, 1999 |
|---|
| Jahr Quelle: | 2023 |
|---|
| Band/Heft Quelle: | 25(2023), 2 vom: Feb., Seite 263-276 |
|---|
| ISSN Quelle: | 1523-5866 |
|---|
| Abstract: | Dendritic cells (DC), the most potent professional antigen presenting cells capable of effective cross-presentation, have been demonstrated to license T helper cells to induce antitumor immunity in solid tumors. Specific DC subtypes are recruited to the injured brain by microglial chemokines, locally adapting to distinct transcriptional profiles. In isocitrate dehydrogenase (IDH) type 1 mutant gliomas, monocyte-derived macrophages have recently been shown to display an attenuated intratumoral antigen presentation capacity as consequence of the local accumulation of the oncometabolite R-2-hydroxyglutarate. The functionality and the contribution of DC to the IDH-mutant tumor microenvironment (TME) remains unclear.Frequencies and intratumoral phenotypes of human DC in IDH-wildtype (IDHwt) and -mutant high-grade gliomas are comparatively assessed by transcriptomic and proteomic profiling. DC functionality is investigated in experimental murine glioblastomas expressing the model antigen ovalbumin. Single-cell sequencing-based pseudotime analyses and spectral flow cytometric analyses are used to profile DC states longitudinally.DC are present in primary and recurrent high-grade gliomas and interact with other immune cell types within the TME. In murine glioblastomas, we find an IDH-status-associated major histocompatibility class I-restricted cross-presentation of tumor antigens by DC specifically in the tumor but not in meninges or secondary lymphoid organs of tumor-bearing animals. In single-cell sequencing-based pseudotime and longitudinal spectral flow cytometric analyses, we demonstrate an IDH-status-dependent differential, exclusively microenvironmental education of DC.Glioma-associated DCs are relevantly abundant in human IDHwt and mutant tumors. Glioma IDH mutations result in specifically educated, dysfunctional DCs via paracrine reprogramming of infiltrating monocytes, providing the basis for combinatorial immunotherapy concepts against IDH mutant gliomas. |
|---|
| DOI: | doi:10.1093/neuonc/noac138 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1093/neuonc/noac138 |
|---|
| | kostenfrei: Volltext: https://academic.oup.com/neuro-oncology/article/25/2/263/6591514?login=true |
|---|
| | DOI: https://doi.org/10.1093/neuonc/noac138 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Bibliogr. Hinweis: | Ergänzung: Prins, Robert M.: Commentary on "Dysfunctional dendritic cells limit antigen-specific T cell response in glioma", in: Neuro-Oncology |(DOI)10.1093/neuonc/noac256 |
|---|
| K10plus-PPN: | 1892088347 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Dysfunctional dendritic cells limit antigen-specific T cell response in glioma / Friedrich, Mirco [VerfasserIn]; February 2023 (Online-Ressource)
Zurück zur Trefferübersicht und Suche
