| |  Online-Ressource |
|---|
| Verfasst von: | Fink, Christoph Andreas [VerfasserIn]  |
|---|
| | Buchele, Carolin [VerfasserIn] |
|---|
| | Baumann, Lukas [VerfasserIn] |
|---|
| | Liermann, Jakob [VerfasserIn] |
|---|
| | Hoegen, Philipp [VerfasserIn] |
|---|
| | Ristau, Jonas [VerfasserIn] |
|---|
| | Regnery, Sebastian [VerfasserIn] |
|---|
| | Sandrini, Elisabetta [VerfasserIn] |
|---|
| | König, Laila [VerfasserIn] |
|---|
| | Rippke, Carolin [VerfasserIn] |
|---|
| | Bonekamp, David [VerfasserIn] |
|---|
| | Schlemmer, Heinz-Peter [VerfasserIn] |
|---|
| | Debus, Jürgen [VerfasserIn] |
|---|
| | Körber, Stefan A. [VerfasserIn] |
|---|
| | Klüter, Sebastian [VerfasserIn] |
|---|
| | Hörner-Rieber, Juliane [VerfasserIn] |
|---|
| Titel: | Dosimetric benefit of online treatment plan adaptation in stereotactic ultrahypofractionated MR-guided radiotherapy for localized prostate cancer |
|---|
| Verf.angabe: | Christoph A. Fink, Carolin Buchele, Lukas Baumann, Jakob Liermann, Philipp Hoegen, Jonas Ristau, Sebastian Regnery, Elisabetta Sandrini, Laila König, Carolin Rippke, David Bonekamp, Heinz-Peter Schlemmer, Juergen Debus, Stefan A. Koerber, Sebastian Klüter and Juliane Hörner-Rieber |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | 15 February 2024 |
|---|
| Umfang: | 7 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Gesehen am 27.05.2024 |
|---|
| Titel Quelle: | Enthalten in: Frontiers in oncology |
|---|
| Ort Quelle: | Lausanne : Frontiers Media, 2011 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 14(2024) vom: Feb., Artikel-ID 1308406, Seite 1-7 |
|---|
| ISSN Quelle: | 2234-943X |
|---|
| Abstract: | <sec><title>Background</title><p>Apart from superior soft tissue contrast, MR-guided stereotactic body radiation therapy (SBRT) offers the chance for daily online plan adaptation. This study reports on the comparison of dose parameters before and after online plan adaptation in MR-guided SBRT of localized prostate cancer.</p></sec><sec><title>Materials and methods</title><p>32 consecutive patients treated with ultrahypofractionated SBRT for localized prostate cancer within the prospective SMILE trial underwent a planning process for MR-guided radiotherapy with 37.5 Gy applied in 5 fractions. A base plan, derived from MRI simulation at an MRIdian Linac, was registered to daily MRI scans (predicted plan). Following target and OAR recontouring, the plan was reoptimized based on the daily anatomy (adapted plan). CTV and PTV coverage and doses at OAR were compared between predicted and adapted plans using linear mixed regression models.</p></sec><sec><title>Results</title><p>In 152 out of 160 fractions (95%), an adapted radiation plan was delivered. Mean CTV and PTV coverage increased by 1.4% and 4.5% after adaptation. 18% vs. 95% of the plans had a PTV coverage ≥95% before and after online adaptation, respectively. 78% vs. 100% of the plans had a CTV coverage ≥98% before and after online adaptation, respectively. The D<sub>0.2cc</sub> for both bladder and rectum were <38.5 Gy in 93% vs. 100% before and after online adaptation. The constraint at the urethra with a dose of <37.5 Gy was achieved in 59% vs. 93% before and after online adaptation.</p></sec><sec><title>Conclusion</title><p>Online adaptive plan adaptation improves target volume coverage and reduces doses to OAR in MR-guided SBRT of localized prostate cancer. Online plan adaptation could potentially further reduce acute and long-term side effects and improve local failure rates in MR-guided SBRT of localized prostate cancer.</p></sec> |
|---|
| DOI: | doi:10.3389/fonc.2024.1308406 |
|---|
| URL: | kostenfrei: Volltext: https://doi.org/10.3389/fonc.2024.1308406 |
|---|
| | kostenfrei: Volltext: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1308406/full |
|---|
| | DOI: https://doi.org/10.3389/fonc.2024.1308406 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | daily adaptive radiotherapy |
|---|
| | Dosimetric benefits |
|---|
| | MR-guided radiotherapy |
|---|
| | prostate cancer |
|---|
| | stereotactic body radiation therapy |
|---|
| K10plus-PPN: | 1889915300 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
| |
|
|---|
| | |
|---|
| Lokale URL UB: |  Zum Volltext |
|---|
Dosimetric benefit of online treatment plan adaptation in stereotactic ultrahypofractionated MR-guided radiotherapy for localized prostate cancer / Fink, Christoph Andreas [VerfasserIn]; 15 February 2024 (Online-Ressource)
Zurück zur Trefferübersicht und Suche
