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| Verfasst von: | Botta, Cirino [VerfasserIn]  |
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| | Perez, Cristina [VerfasserIn] |
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| | Larrayoz, Marta [VerfasserIn] |
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| | Puig, Noemi [VerfasserIn] |
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| | Cedena, Maria-Teresa [VerfasserIn] |
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| | Termini, Rosalinda [VerfasserIn] |
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| | Goicoechea, Ibai [VerfasserIn] |
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| | Rodriguez, Sara [VerfasserIn] |
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| | Zabaleta, Aintzane [VerfasserIn] |
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| | Lopez, Aitziber [VerfasserIn] |
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| | Sarvide, Sarai [VerfasserIn] |
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| | Blanco, Laura [VerfasserIn] |
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| | Papetti, Daniele M. [VerfasserIn] |
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| | Nobile, Marco S. [VerfasserIn] |
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| | Besozzi, Daniela [VerfasserIn] |
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| | Gentile, Massimo [VerfasserIn] |
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| | Correale, Pierpaolo [VerfasserIn] |
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| | Siragusa, Sergio [VerfasserIn] |
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| | Oriol, Albert [VerfasserIn] |
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| | González-Garcia, Maria Esther [VerfasserIn] |
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| | Sureda, Anna [VerfasserIn] |
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| | de Arriba, Felipe [VerfasserIn] |
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| | Rios Tamayo, Rafael [VerfasserIn] |
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| | Moraleda, Jose-Maria [VerfasserIn] |
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| | Gironella, Mercedes [VerfasserIn] |
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| | Hernandez, Miguel T. [VerfasserIn] |
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| | Bargay, Joan [VerfasserIn] |
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| | Palomera, Luis [VerfasserIn] |
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| | Pérez-Montaña, Albert [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Avet-Loiseau, Hervé [VerfasserIn] |
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| | Roccaro, Aldo [VerfasserIn] |
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| | Orfao, Alberto [VerfasserIn] |
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| | Martinez-Lopez, Joaquin [VerfasserIn] |
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| | Rosiñol, Laura [VerfasserIn] |
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| | Lahuerta, Juan-José [VerfasserIn] |
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| | Blade, Joan [VerfasserIn] |
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| | Mateos, Maria-Victoria [VerfasserIn] |
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| | San-Miguel, Jesús F. [VerfasserIn] |
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| | Martinez Climent, Jose-Angel [VerfasserIn] |
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| | Paiva, Bruno [VerfasserIn] |
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| Titel: | Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance |
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| Verf.angabe: | Cirino Botta, Cristina Perez, Marta Larrayoz, Noemi Puig, Maria-Teresa Cedena, Rosalinda Termini, Ibai Goicoechea, Sara Rodriguez, Aintzane Zabaleta, Aitziber Lopez, Sarai Sarvide, Laura Blanco, Daniele M. Papetti, Marco S. Nobile, Daniela Besozzi, Massimo Gentile, Pierpaolo Correale, Sergio Siragusa, Albert Oriol, Maria Esther González-Garcia, Anna Sureda, Felipe de Arriba, Rafael Rios Tamayo, Jose-Maria Moraleda, Mercedes Gironella, Miguel T. Hernandez, Joan Bargay, Luis Palomera, Albert Pérez-Montaña, Hartmut Goldschmidt, Hervé Avet-Loiseau, Aldo Roccaro, Alberto Orfao, Joaquin Martinez-Lopez, Laura Rosiñol, Juan-José Lahuerta, Joan Blade, Maria-Victoria Mateos, Jesús F. San-Miguel, Jose-Angel Martinez Climent, Bruno Paiva, the Programa Para el Estudio de la Terapéutica en Hemopatías Malignas/Grupo Español de Mieloma (PETHEMA/GEM) cooperative group and the iMMunocell study group |
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| E-Jahr: | 2023 |
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| Jahr: | 20 September 2023 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 23.04.2024 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 14(2023), Artikel-ID 5825, Seite 1-15 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). Here, we use single-cell RNA and T cell receptor sequencing to characterize bone marrow T cells from healthy adults (n = 4) and patients with precursor (n = 8) and full-blown MM (n = 10). Large T cell clones from patients with MM expressed multiple immune checkpoints, suggesting a potentially dysfunctional phenotype. Dual targeting of PD-1 + LAG3 or PD-1 + TIGIT partially restored their function in mice with MM. We identify phenotypic hallmarks of large intratumoral T cell clones, and demonstrate that the CD27− and CD27+ T cell ratio, measured by flow cytometry, may serve as a surrogate of clonal T cell expansions and an independent prognostic factor in 543 patients with MM treated with lenalidomide-based treatment combinations. |
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| DOI: | doi:10.1038/s41467-023-41562-6 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-023-41562-6 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-023-41562-6 |
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| | DOI: https://doi.org/10.1038/s41467-023-41562-6 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Myeloma |
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| | Tumour immunology |
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| | VDJ recombination |
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| K10plus-PPN: | 1886589968 |
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| Verknüpfungen: | → Zeitschrift |
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Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance / Botta, Cirino [VerfasserIn]; 20 September 2023 (Online-Ressource)
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