Navigation überspringen
Universitätsbibliothek Heidelberg
Trefferliste Zurück zur Trefferübersicht und Suche
disk Markieren   Persönliche Notiz
Drucker
Andere Formate
Exportieren/Zitieren
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Bergeman, Auke T. [VerfasserIn]   i
 Lieve, Krystien V.V. [VerfasserIn]   i
 Kallas, Dania [VerfasserIn]   i
 Bos, J. Martijn [VerfasserIn]   i
 Rosés i Noguer, Ferran [VerfasserIn]   i
 Denjoy, Isabelle [VerfasserIn]   i
 Zorio, Esther [VerfasserIn]   i
 Kammeraad, Janneke A.E. [VerfasserIn]   i
 Peltenburg, Puck J. [VerfasserIn]   i
 Tobert, Katie [VerfasserIn]   i
 Aiba, Takeshi [VerfasserIn]   i
 Atallah, Joseph [VerfasserIn]   i
 Drago, Fabrizio [VerfasserIn]   i
 Batra, Anjan S. [VerfasserIn]   i
 Brugada, Ramon [VerfasserIn]   i
 Borggrefe, Martin [VerfasserIn]   i
 Clur, Sally-Ann B. [VerfasserIn]   i
 Cox, Moniek G.P.J. [VerfasserIn]   i
 Davis, Andrew [VerfasserIn]   i
 Dhillon, Santokh [VerfasserIn]   i
 Etheridge, Susan P. [VerfasserIn]   i
 Fischbach, Peter [VerfasserIn]   i
 Franciosi, Sonia [VerfasserIn]   i
 Haugaa, Kristina [VerfasserIn]   i
 Horie, Minoru [VerfasserIn]   i
 Johnsrude, Christopher [VerfasserIn]   i
 Kane, Austin M. [VerfasserIn]   i
 Krause, Ulrich [VerfasserIn]   i
 Kwok, Sit-Yee [VerfasserIn]   i
 LaPage, Martin J. [VerfasserIn]   i
 Ohno, Seiko [VerfasserIn]   i
 Probst, Vincent [VerfasserIn]   i
 Roberts, Jason D. [VerfasserIn]   i
 Robyns, Tomas [VerfasserIn]   i
 Sacher, Frederic [VerfasserIn]   i
 Semsarian, Christopher [VerfasserIn]   i
 Skinner, Jonathan R. [VerfasserIn]   i
 Swan, Heikki [VerfasserIn]   i
 Tavacova, Terezia [VerfasserIn]   i
 Tisma-Dupanovic, Svjetlana [VerfasserIn]   i
 Tfelt-Hansen, Jacob [VerfasserIn]   i
 Yap, Sing-Chien [VerfasserIn]   i
 Kannankeril, Prince J. [VerfasserIn]   i
 Leenhardt, Antoine [VerfasserIn]   i
 Till, Janice [VerfasserIn]   i
 Sanatani, Shubhayan [VerfasserIn]   i
 Tanck, Michael W.T. [VerfasserIn]   i
 Ackerman, Michael J. [VerfasserIn]   i
 Wilde, Arthur A.M. [VerfasserIn]   i
 van der Werf, Christian [VerfasserIn]   i
Titel:Flecainide is associated with a lower incidence of arrhythmic events in a large cohort of patients with catecholaminergic polymorphic ventricular tachycardia
Titelzusatz:original research article
Verf.angabe:Auke T. Bergeman, MD, Krystien V.V. Lieve, MD, PhD, Dania Kallas, MS, J. Martijn Bos, MD, PhD, Ferran Rosés i Noguer, MD, Isabelle Denjoy, MD, Esther Zorio, MD, PhD, Janneke A.E. Kammeraad, MD, PhD, Puck J. Peltenburg, MD, Katie Tobert, BA, Takeshi Aiba, MD, Joseph Atallah, MD, CM, SM, Fabrizio Drago, MD, Anjan S. Batra, MD, Ramon Brugada, MD, Martin Borggrefe, MD, Sally-Ann B. Clur, MSc, PhD, Moniek G.P.J. Cox, MD, PhD, Andrew Davis, MB, BS, MD, Santokh Dhillon, MD, Susan P. Etheridge, MD, Peter Fischbach, MD, Sonia Franciosi, PhD, Kristina Haugaa, MD, PhD, Minoru Horie, MD, PhD, Christopher Johnsrude, MD, MS, Austin M. Kane, MD, Ulrich Krause, MD, Sit-Yee Kwok, MD, Martin J. LaPage, MD, MS, Seiko Ohno, MD, PhD, Vincent Probst, MD, Jason D. Roberts, MD, MAS, Tomas Robyns, MD, Frederic Sacher, MD, Christopher Semsarian, MB, BS, MPH, Jonathan R. Skinner, MD, Heikki Swan, MD, Terezia Tavacova, MD, Svjetlana Tisma-Dupanovic, MD, Jacob Tfelt-Hansen, MD, DMSc, Sing-Chien Yap, MD, PhD, Prince J. Kannankeril, MD, Antoine Leenhardt, MD, Janice Till, MBBS, Bsc, MD, Shubhayan Sanatani, MD, Michael W.T. Tanck, MSc, PhD,, Michael J. Ackerman, MD, PhD, Arthur A.M. Wilde, MD, PhD, Christian van der Werf, MD, PhD
E-Jahr:2023
Jahr:December 19, 2023
Umfang:9 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 27. Oktober 2023 ; Gesehen am 11.04.2024
Titel Quelle:Enthalten in: Circulation
Ort Quelle:Philadelphia, Pa. : Lippincott, Williams & Wilkins, 1950
Jahr Quelle:2023
Band/Heft Quelle:148(2023), 25 vom: Dez., Seite 2029-2037
ISSN Quelle:1524-4539
Abstract:BACKGROUND: In severely affected patients with catecholaminergic polymorphic ventricular tachycardia, beta-blockers are often insufficiently protective. The purpose of this study was to evaluate whether flecainide is associated with a lower incidence of arrhythmic events (AEs) when added to beta-blockers in a large cohort of patients with catecholaminergic polymorphic ventricular tachycardia. METHODS: From 2 international registries, this multicenter case cross-over study included patients with a clinical or genetic diagnosis of catecholaminergic polymorphic ventricular tachycardia in whom flecainide was added to beta-blocker therapy. The study period was defined as the period in which background therapy (ie, beta-blocker type [beta1-selective or nonselective]), left cardiac sympathetic denervation, and implantable cardioverter defibrillator treatment status, remained unchanged within individual patients and was divided into pre-flecainide and on-flecainide periods. The primary end point was AEs, defined as sudden cardiac death, sudden cardiac arrest, appropriate implantable cardioverter defibrillator shock, and arrhythmic syncope. The association of flecainide with AE rates was assessed using a generalized linear mixed model assuming negative binomial distribution and random effects for patients. RESULTS: A total of 247 patients (123 [50%] females; median age at start of flecainide, 18 years [interquartile range, 14-29]; median flecainide dose, 2.2 mg/kg per day [interquartile range, 1.7-3.1]) were included. At baseline, all patients used a beta-blocker, 70 (28%) had an implantable cardioverter defibrillator, and 21 (9%) had a left cardiac sympathetic denervation. During a median pre-flecainide follow-up of 2.1 years (interquartile range, 0.4-7.2), 41 patients (17%) experienced 58 AEs (annual event rate, 5.6%). During a median on-flecainide follow-up of 2.9 years (interquartile range, 1.0-6.0), 23 patients (9%) experienced 38 AEs (annual event rate, 4.0%). There were significantly fewer AEs after initiation of flecainide (incidence rate ratio, 0.55 [95% CI, 0.38-0.83]; P=0.007). Among patients who were symptomatic before diagnosis or during the pre-flecainide period (n=167), flecainide was associated with significantly fewer AEs (incidence rate ratio, 0.49 [95% CI, 0.31-0.77]; P=0.002). Among patients with ≥1 AE on beta-blocker therapy (n=41), adding flecainide was also associated with significantly fewer AEs (incidence rate ratio, 0.25 [95% CI, 0.14-0.45]; P<0.001). CONCLUSIONS: For patients with catecholaminergic polymorphic ventricular tachycardia, adding flecainide to beta-blocker therapy was associated with a lower incidence of AEs in the overall cohort, in symptomatic patients, and particularly in patients with breakthrough AEs while on beta-blocker therapy.
DOI:doi:10.1161/CIRCULATIONAHA.123.064786
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1161/CIRCULATIONAHA.123.064786
 kostenfrei: Volltext: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064786
 DOI: https://doi.org/10.1161/CIRCULATIONAHA.123.064786
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:catecholaminergic polymorphic ventricular tachycardia
 sudden cardiac death
 ventricular arrhythmias
K10plus-PPN:1885600399
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69199721   QR-Code

zum Seitenanfang

© Universitätsbibliothek HeidelbergMailImpressum / Datenschutz   Design