| |  Online-Ressource |
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| Verfasst von: | Arndts, Kathrin [VerfasserIn]  |
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| | Kegele, Josua [VerfasserIn] |
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| | Massarani, Alain S. [VerfasserIn] |
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| | Ritter, Manuel [VerfasserIn] |
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| | Wagner, Thomas [VerfasserIn] |
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| | Pfarr, Kenneth [VerfasserIn] |
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| | Lämmer, Christine [VerfasserIn] |
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| | Dörmann, Peter [VerfasserIn] |
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| | Peisker, Helga [VerfasserIn] |
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| | Menche, Dirk [VerfasserIn] |
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| | Al-Bahra, Mazen [VerfasserIn] |
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| | Costa, Clarissa Prazeres da [VerfasserIn] |
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| | Schmutzhard, Erich [VerfasserIn] |
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| | Matuja, William [VerfasserIn] |
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| | Hoerauf, Achim [VerfasserIn] |
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| | Layland-Heni, Laura E. [VerfasserIn] |
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| | Winkler, Andrea Sylvia [VerfasserIn] |
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| Titel: | Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns |
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| Verf.angabe: | Kathrin Arndts, Josua Kegele, Alain S. Massarani, Manuel Ritter, Thomas Wagner, Kenneth Pfarr, Christine Lämmer, Peter Dörmann, Helga Peisker, Dirk Menche, Mazen Al-Bahra, Clarissa Prazeres da Costa, Erich Schmutzhard, William Matuja, Achim Hoerauf, Laura E. Layland-Heni, Andrea S. Winkler |
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| E-Jahr: | 2023 |
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| Jahr: | August 3, 2023 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 07.02.2024 |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS neglected tropical diseases |
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| Ort Quelle: | Lawrence, Kan. : PLoS, 2007 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 17(2023), 8, Artikel-ID 0011503, Seite 1-20 |
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| ISSN Quelle: | 1935-2735 |
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| Abstract: | Previous studies have described the association of onchocerciasis (caused by Onchocerca volvulus) with epilepsy, including nodding syndrome, although a clear etiological link is still missing. Cases are found in different African countries (Tanzania, South Sudan, Uganda, Democratic Republic of the Congo, Central African Republic and Cameroon). In our study we investigated immunological parameters (cytokine, chemokine, immunoglobulin levels) in individuals from the Mahenge area, Tanzania, presenting with either epilepsy or nodding syndrome with or without O. volvulus infection and compared them to O. volvulus negative individuals from the same endemic area lacking neurological disorders. Additionally, cell differentiation was performed using blood smears and systemic levels of neurodegeneration markers, leiomodin-1 and N-acetyltyramine-O, β-glucuronide (NATOG) were determined. Our findings revealed that cytokines, most chemokines and neurodegeneration markers were comparable between both groups presenting with epilepsy or nodding syndrome. However, we observed elevated eosinophil percentages within the O. volvulus positive epilepsy/nodding syndrome patients accompanied with increased eosinophilic cationic protein (ECP) and antigen-specific IgG levels in comparison to those without an O. volvulus infection. Furthermore, highest levels of NATOG were found in O. volvulus positive nodding syndrome patients. These findings highlight that the detection of distinct biomarkers might be useful for a differential diagnosis of epilepsy and nodding syndrome in O. volvulus endemic areas. Trial-registration: NCT03653975. |
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| DOI: | doi:10.1371/journal.pntd.0011503 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1371/journal.pntd.0011503 |
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| | kostenfrei: Volltext: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011503 |
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| | DOI: https://doi.org/10.1371/journal.pntd.0011503 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Chemokines |
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| | Enzyme-linked immunoassays |
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| | Eosinophils |
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| | Epilepsy |
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| | Onchocerca volvulus |
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| | Onchocerciasis |
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| | Parasitic diseases |
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| | Urine |
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| K10plus-PPN: | 1880238799 |
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| Verknüpfungen: | → Zeitschrift |
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Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns / Arndts, Kathrin [VerfasserIn]; August 3, 2023 (Online-Ressource)
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