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| Verfasst von: | Pyatilova, Polina [VerfasserIn]  |
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| | Akin, Cem [VerfasserIn] |
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| | Alvarez-Twose, Iván [VerfasserIn] |
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| | Arock, Michel [VerfasserIn] |
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| | Bonadonna, Patrizia [VerfasserIn] |
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| | Brockow, Knut [VerfasserIn] |
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| | Butterfield, Joseph H. [VerfasserIn] |
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| | Broesby-Olsen, Sigurd [VerfasserIn] |
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| | Carter, Melody C. [VerfasserIn] |
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| | Castells, Mariana [VerfasserIn] |
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| | George, Tracy I. [VerfasserIn] |
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| | Gotlib, Jason [VerfasserIn] |
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| | Greiner, Georg [VerfasserIn] |
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| | Gülen, Theo [VerfasserIn] |
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| | Hartmann, Karin [VerfasserIn] |
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| | Hermine, Olivier [VerfasserIn] |
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| | Horny, Hans-Peter [VerfasserIn] |
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| | Jawhar, Mohamad [VerfasserIn] |
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| | Lange, Magdalena [VerfasserIn] |
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| | Lyons, Jonathan J. [VerfasserIn] |
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| | Maurer, Marcus [VerfasserIn] |
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| | Metcalfe, Dean D. [VerfasserIn] |
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| | Nedoszytko, Boguslaw [VerfasserIn] |
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| | Niedoszytko, Marek [VerfasserIn] |
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| | Orfao, Alberto [VerfasserIn] |
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| | Reiter, Andreas [VerfasserIn] |
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| | Schwaab, Juliana [VerfasserIn] |
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| | Sotlar, Karl [VerfasserIn] |
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| | Sperr, Wolfgang R. [VerfasserIn] |
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| | Triggiani, Massimo [VerfasserIn] |
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| | Valent, Peter [VerfasserIn] |
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| | Siebenhaar, Frank [VerfasserIn] |
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| Titel: | Refined treatment response criteria for indolent systemic mastocytosis proposed by the ECNM-AIM consortium |
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| Verf.angabe: | Polina Pyatilova, Cem Akin, Iván Alvarez-Twose, Michel Arock, Patrizia Bonadonna, Knut Brockow, Joseph H. Butterfield, Sigurd Broesby-Olsen, Melody C. Carter, Mariana Castells, Tracy I. George, Jason Gotlib, Georg Greiner, Theo Gülen, Karin Hartmann, Olivier Hermine, Hans-Peter Horny, Mohamed Jawhar, Magdalena Lange, Jonathan J. Lyons, Marcus Maurer, Dean D. Metcalfe, Boguslaw Nedoszytko, Marek Niedoszytko, Alberto Orfao, Andreas Reiter, Juliana Schwaab, Karl Sotlar, Wolfgang R. Sperr, Massimo Triggiani, Peter Valent, Frank Siebenhaar |
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| E-Jahr: | 2022 |
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| Jahr: | August 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Online verfügbar: 18 June 2022, Artikelversion: 9 August 2022 ; Der Autor Jawhar, Mohamad ist fälschlich Jawhar, Mohamed geschrieben ; Gesehen am 30.10.2023 |
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| Titel Quelle: | Enthalten in: The journal of allergy and clinical immunology / In practice |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 10(2022), 8, Seite 2015-2024 |
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| ISSN Quelle: | 2213-2201 |
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| Abstract: | Indolent systemic mastocytosis (ISM) has a favorable prognosis and normal life expectancy. However, many patients suffer from mast cell (MC) mediator-related symptoms, which significantly affect quality of life (QoL). Cutaneous, gastrointestinal, and neurological complaints, musculoskeletal pain, and the presence of skin lesions, anaphylaxis, and osteoporosis are the main symptoms and signs in ISM and must be assessed in all patients before and during treatment. Validated mastocytosis-specific patient-reported outcome measures (PROMs) should be used for this purpose. Serum tryptase and KIT D816V allele burden are recommended as secondary outcome parameters, noting that they do not reflect the severity of signs, symptoms, and related QoL impairment, but indirectly express MC burden. Changes from baseline of 90%, 60%, and 30% indicate complete response >90%, major response 60% to 90%, partial response 30% to 60%, and no response <30% to treatment. To conclude, we recommend the use of PROMs as primary outcome parameters to define treatment response in patients with ISM in clinical trials and in everyday clinical practice. |
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| DOI: | doi:10.1016/j.jaip.2022.05.037 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jaip.2022.05.037 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2213219822005888 |
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| | DOI: https://doi.org/10.1016/j.jaip.2022.05.037 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Mast cell activation |
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| | Mast cells |
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| | Mastocytosis |
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| | Response criteria |
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| | Signs |
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| | Symptoms |
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| K10plus-PPN: | 1868815587 |
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| Verknüpfungen: | → Zeitschrift |
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Refined treatment response criteria for indolent systemic mastocytosis proposed by the ECNM-AIM consortium / Pyatilova, Polina [VerfasserIn]; August 2022 (Online-Ressource)
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