| |  Online-Ressource |
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| Verfasst von: | Saemann, Lars [VerfasserIn]  |
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| | Wernstedt, Lena [VerfasserIn] |
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| | Pohl, Sabine [VerfasserIn] |
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| | Stiller, Markus [VerfasserIn] |
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| | Willsch, Jan [VerfasserIn] |
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| | Hofmann, Britt [VerfasserIn] |
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| | Veres, Gábor [VerfasserIn] |
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| | Simm, Andreas [VerfasserIn] |
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| | Szabó, Gábor [VerfasserIn] |
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| Titel: | Impact of age on endothelial function of saphenous vein grafts in coronary artery bypass grafting |
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| Verf.angabe: | Lars Saemann, Lena Wernstedt, Sabine Pohl, Markus Stiller, Jan Willsch, Britt Hofmann, Gábor Veres, Andreas Simm and Gábor Szabó |
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| Jahr: | 2023 |
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| Umfang: | 17 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 22. August 2023 ; Gesehen am 25.10.2023 |
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| Titel Quelle: | Enthalten in: Journal of Clinical Medicine |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 12(2023), 17, Artikel-ID 5454, Seite 1-17 |
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| ISSN Quelle: | 2077-0383 |
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| Abstract: | Background: An intact and functionally preserved endothelial layer in the graft is crucial for myocardial perfusion and graft patency after coronary artery bypass grafting (CABG). We hypothesized that old age is a risk factor for decreased endothelial function of bypass grafts. Thus, we investigated the impact of age in patients treated with CABG on endothelial function in saphenous vein grafts. Methods: We mounted the saphenous vein graft segments of CABG patients < 70 (n = 33) and ≥70 (n = 40) years of age in organ bath chambers and exposed them to potassium chloride (KCl) and phenylephrine (PE) to test the receptor-independent and -dependent contractility, followed by exposure to acetylcholine (ACh) and sodium nitroprusside (SNP) to test the endothelial-dependent and -independent relaxation. Results: The maximal contraction induced by KCl (2.3 ± 1.8 vs. 1.8 ± 2 g) was stronger in patients ≥ 70 years of age. The relative contraction induced by PE in % of KCl (167 ± 64 vs. 163 ± 59%) was similar between groups. Patients aged < 70 years showed a higher endothelial-dependent relaxation induced by acetylcholine than patients ≥ 70 years (51 ± 27 vs. 42 ± 18%). The relaxation induced by SNP was similar between both groups. Conclusions: The endothelial function of saphenous vein bypass grafts decreases during aging. Thus, age should be considered when improving graft maintenance. |
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| DOI: | doi:10.3390/jcm12175454 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/jcm12175454 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2077-0383/12/17/5454 |
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| | DOI: https://doi.org/10.3390/jcm12175454 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | aging |
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| | coronary artery bypass grafting (CABG) |
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| | coronary artery disease |
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| | endothelium |
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| | saphenous vein |
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| | senescence |
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| K10plus-PPN: | 1867620928 |
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| Verknüpfungen: | → Zeitschrift |
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Impact of age on endothelial function of saphenous vein grafts in coronary artery bypass grafting / Saemann, Lars [VerfasserIn]; 2023 (Online-Ressource)
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