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| Verfasst von: | Gotlib, Jason [VerfasserIn]  |
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| | Schwaab, Juliana [VerfasserIn] |
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| | Shomali, William [VerfasserIn] |
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| | George, Tracy I. [VerfasserIn] |
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| | Radia, Deepti H. [VerfasserIn] |
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| | Castells, Mariana [VerfasserIn] |
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| | Carter, Melody C. [VerfasserIn] |
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| | Hartmann, Karin [VerfasserIn] |
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| | Álvarez-Twose, Ivan [VerfasserIn] |
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| | Brockow, Knut [VerfasserIn] |
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| | Bonadonna, Patrizia [VerfasserIn] |
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| | Hermine, Olivier [VerfasserIn] |
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| | Niedoszytko, Marek [VerfasserIn] |
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| | Hoermann, Gregor [VerfasserIn] |
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| | Sperr, Wolfgang R. [VerfasserIn] |
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| | Elberink, Hanneke Oude [VerfasserIn] |
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| | Siebenhaar, Frank [VerfasserIn] |
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| | Butterfield, Joseph H. [VerfasserIn] |
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| | Ustun, Celalettin [VerfasserIn] |
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| | Zanotti, Roberta [VerfasserIn] |
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| | Triggiani, Massimo [VerfasserIn] |
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| | Schwartz, Lawrence B. [VerfasserIn] |
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| | Lyons, Jonathan J. [VerfasserIn] |
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| | Orfao, Alberto [VerfasserIn] |
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| | Sotlar, Karl [VerfasserIn] |
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| | Horny, Hans-Peter [VerfasserIn] |
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| | Arock, Michel [VerfasserIn] |
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| | Metcalfe, Dean D. [VerfasserIn] |
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| | Akin, Cem [VerfasserIn] |
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| | Lübke, Johannes [VerfasserIn] |
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| | Valent, Peter [VerfasserIn] |
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| | Reiter, Andreas [VerfasserIn] |
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| Titel: | Proposed European Competence Network on Mastocytosis-American Initiative in Mast Cell Diseases (ECNM-AIM) response criteria in advanced systemic mastocytosis |
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| Verf.angabe: | Jason Gotlib, Juliana Schwaab, William Shomali, Tracy I. George, Deepti H. Radia, Mariana Castells, Melody C. Carter, Karin Hartmann, Ivan Álvarez-Twose, Knut Brockow, Patrizia Bonadonna, Olivier Hermine, Marek Niedoszytko, Gregor Hoermann, Wolfgang R. Sperr, Hanneke Oude Elberink, Frank Siebenhaar, Joseph H. Butterfield, Celalettin Ustun, Roberta Zanotti, Massimo Triggiani, Lawrence B. Schwartz, Jonathan J. Lyons, Alberto Orfao, Karl Sotlar, Hans-Peter Horny, Michel Arock, Dean D. Metcalfe, Cem Akin, Johannes Lübke, Peter Valent, Andreas Reiter |
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| E-Jahr: | 2022 |
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| Jahr: | August 2022 |
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| Umfang: | 14 S. |
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| Fussnoten: | Online verfügbar: 18 June 2022, Artikelversion: 9 August 2022 ; Gesehen am 17.10.2023 |
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| Titel Quelle: | Enthalten in: The journal of allergy and clinical immunology / In practice |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 10(2022), 8 vom: Aug., Seite 2025-2038.e1 |
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| ISSN Quelle: | 2213-2201 |
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| Abstract: | Advanced systemic mastocytosis (AdvSM) is characterized by the presence of KIT D816V and other somatic mutations (eg, in SRSF2, ASXL1, and RUNX1) in 95% and 60% to 70% of patients, respectively. The biological and clinical consequences of AdvSM include multilineage involvement (eg, associated hematologic neoplasm) in 60% to 80% of patients, variable infiltration and damage (C-findings) of predominantly bone marrow and visceral organs through affected mast cell (MC) and non-MC lineages, and elevated levels of serum tryptase. Recently, the treatment landscape has substantially changed with the introduction of the multikinase/KIT inhibitor midostaurin and the selective KIT D816V inhibitor avapritinib. In this review, we discuss the evolution of AdvSM response criteria that have been developed to better capture clinical benefit (eg, improved responses and progression-free and overall survival). We propose refined response criteria from European Competence Network on Mastocytosis and American Initiative in Mast Cell Diseases investigators that use a tiered approach to segregate the effects of histopathologic (eg, bone marrow MC burden, tryptase), molecular (eg, KIT D816V variant allele frequency), clinical (eg, C-findings), and symptom response on long-term outcomes. These response criteria require evaluation in future prospective clinical trials of selective KIT inhibitors and other novel agents. |
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| DOI: | doi:10.1016/j.jaip.2022.05.034 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jaip.2022.05.034 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2213219822005852 |
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| | DOI: https://doi.org/10.1016/j.jaip.2022.05.034 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Advanced systemic mastocytosis |
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| | Avapritinib |
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| | International Working-Group for Myeloproliferative Neoplasms Research and Treatment and European Competence Network on Mastocytosis |
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| | KIT D816V |
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| | Midostaurin |
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| | Pure pathologic response |
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| K10plus-PPN: | 186593447X |
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| Verknüpfungen: | → Zeitschrift |
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Proposed European Competence Network on Mastocytosis-American Initiative in Mast Cell Diseases (ECNM-AIM) response criteria in advanced systemic mastocytosis / Gotlib, Jason [VerfasserIn]; August 2022 (Online-Ressource)
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