| |  Online-Ressource |
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| Verfasst von: | Rompen, Ingmar F. [VerfasserIn]  |
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| | Nienhüser, Henrik [VerfasserIn] |
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| | Crnovrsanin, Nerma [VerfasserIn] |
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| | Musa, Julian [VerfasserIn] |
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| | Haag, Georg Martin [VerfasserIn] |
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| | Longerich, Thomas [VerfasserIn] |
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| | Fiedler, Timon [VerfasserIn] |
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| | Müller, Beat P. [VerfasserIn] |
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| | Peters, Leila [VerfasserIn] |
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| | Billeter, Adrian [VerfasserIn] |
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| Titel: | Clinical characteristics and oncological outcomes of surgically treated early-onset gastric adenocarcinoma - a retrospective cohort study |
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| Verf.angabe: | Ingmar F. Rompen, Henrik Nienhüser, Nerma Crnovrsanin, Julian Musa, Georg Martin Haag, Thomas Longerich, Timon Fiedler, Beat P. Müller-Stich, Leila Sisic, Adrian T. Billeter |
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| Jahr: | 2023 |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 21.5.2023 ; Gesehen am 28.09.2023 |
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| Titel Quelle: | Enthalten in: Journal of cancer |
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| Ort Quelle: | Wyoming, NSW : Ivyspring Internat. Publ., 2010 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 14(2023), 9, Seite 1470-1478 |
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| ISSN Quelle: | 1837-9664 |
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| Abstract: | Introduction: The incidence of early-onset gastric adenocarcinoma (patients <50 years, EOGA) is rising. Tumors in younger patients are associated with prognostically unfavorable features. The impact of EOGA on patient survival, however, remains unclear. The aim of this study is to evaluate early-onset age as a prognostic factor compared to late-onset gastric adenocarcinoma (LOGA, >50years) in a surgical cohort and assesstreatment options. Methods: We analyzed 738 patients (129 early-onset/609 late-onset) operated in curative intent from 2002 to 2021. Data was extracted from a prospectively managed database of an academic tertiary referral hospital. Differences in perioperative as well as oncological outcomes were calculated by chi-square test. Cox regression analysis was performed to assess disease-free survival (DFS) and overall survival (OS). Results: EOGA patients were more often treated with neoadjuvant therapy (62.8% vs. 43.7%, p<0.001) and extended surgical resections e.g. through additional resections (36.4% vs. 26.8%, p=0.027). EOGA was more often metastasized into regional lymph nodes (pN+ 67.4% vs. 55.3%, p=0.012) and to distant sites (pM+: 23.3% vs. 12.0%, p=0.001) and was more often poorly differentiated (G3/G4: 91.1% vs. 67.2%, p<0.001). There were no significant differences in overall complication rates (31.0% vs. 36.6%, p=0.227). Survival analysis showed shorter DFS (median DFS 25.6 months vs. not reached, p=0.006) but similar OS (median OS: 50.5 months vs. not reached, p=0.920) in EOGA compared to LOGA. Conclusions: This analysis confirmed that EOGA is associated with more aggressive tumor characteristics. Early-Onset was not a prognostic factor in the multivariate analysis. EOGA patients may be more capable to undergo intensive multimodal therapy including perioperative chemotherapy and extended surgery. |
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| DOI: | doi:10.7150/jca.82876 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7150/jca.82876 |
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| | Volltext: https://www.jcancer.org/v14p1470.htm |
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| | DOI: https://doi.org/10.7150/jca.82876 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1860412653 |
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| Verknüpfungen: | → Zeitschrift |
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Clinical characteristics and oncological outcomes of surgically treated early-onset gastric adenocarcinoma - a retrospective cohort study / Rompen, Ingmar F. [VerfasserIn]; 2023 (Online-Ressource)
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