| |  Online-Ressource |
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| Verfasst von: | Özbay Kurt, Feyza Gül [VerfasserIn]  |
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| | Lepper, Alisa [VerfasserIn] |
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| | Gerhards, Catharina [VerfasserIn] |
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| | Römer, Mathis [VerfasserIn] |
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| | Lasser, Samantha [VerfasserIn] |
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| | Arkhypov, Ihor [VerfasserIn] |
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| | Weber, Rebekka [VerfasserIn] |
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| | Bugert, Peter [VerfasserIn] |
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| | Altevogt, Peter [VerfasserIn] |
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| | Gouttefangeas, Cécile [VerfasserIn] |
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| | Neumaier, Michael [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Umansky, Viktor [VerfasserIn] |
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| Titel: | Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2 |
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| Verf.angabe: | Feyza Gül Özbay Kurt, Alisa Lepper, Catharina Gerhards, Mathis Roemer, Samantha Lasser, Ihor Arkhypov, Rebekka Bitsch, Peter Bugert, Peter Altevogt, Cécile Gouttefangeas, Michael Neumaier, Jochen Utikal and Viktor Umansky |
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| E-Jahr: | 2022 |
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| Jahr: | 12 October 2022 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 14.08.2023 |
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| Titel Quelle: | Enthalten in: Frontiers in immunology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2010 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022) vom: Okt., Artikel-ID 1012526, Seite 1-13 |
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| ISSN Quelle: | 1664-3224 |
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| Abstract: | A gradual decay in humoral and cellular immune responses over time upon SAR1S-CoV-2 vaccination may cause a lack of protective immunity. We conducted a longitudinal analysis of antibodies, T cells, and monocytes in 25 participants vaccinated with mRNA or ChAdOx1-S up to 12 weeks after the 3rd (booster) dose with mRNA vaccine. We observed a substantial increase in antibodies and CD8 T cells specific for the spike protein of SARS-CoV-2 after vaccination. Moreover, vaccination induced activated T cells expressing CD69, CD137 and producing IFN-γ and TNF-α. Virus-specific CD8 T cells showed predominantly memory phenotype. Although the level of antibodies and frequency of virus-specific T cells reduced 4-6 months after the 2nd dose, they were augmented after the 3rd dose followed by a decrease later. Importantly, T cells generated after the 3rd vaccination were also reactive against Omicron variant, indicated by a similar level of IFN-γ production after stimulation with Omicron peptides. Breakthrough infection in participants vaccinated with two doses induced more SARS-CoV-2-specific T cells than the booster vaccination. We found an upregulation of PD-L1 expression on monocytes but no accumulation of myeloid cells with MDSC-like immunosuppressive phenotype after the vaccination. Our results indicate that the 3rd vaccination fosters antibody and T cell immune response independently from vaccine type used for the first two injections. However, such immune response is attenuated over time, suggesting thereby the need for further vaccinations. |
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| DOI: | doi:10.3389/fimmu.2022.1012526 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3389/fimmu.2022.1012526 |
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| | kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012526 |
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| | DOI: https://doi.org/10.3389/fimmu.2022.1012526 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1856128849 |
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| Verknüpfungen: | → Zeitschrift |
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Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2 / Özbay Kurt, Feyza Gül [VerfasserIn]; 12 October 2022 (Online-Ressource)
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