| |  Online-Ressource |
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| Verfasst von: | Hasseli, Rebecca [VerfasserIn]  |
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| | Richter, Jutta G. [VerfasserIn] |
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| | Hoyer, Bimba Franziska [VerfasserIn] |
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| | Lorenz, Hanns-Martin [VerfasserIn] |
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| | Pfeil, Alexander [VerfasserIn] |
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| | Regierer, Anne Constanze [VerfasserIn] |
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| | Schmeiser, Tim [VerfasserIn] |
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| | Strangfeld, Anja [VerfasserIn] |
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| | Voll, Reinhard E. [VerfasserIn] |
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| | Krause, Andreas [VerfasserIn] |
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| | Reckert, Sabine [VerfasserIn] |
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| | Gräßler, Anett [VerfasserIn] |
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| | Saar, Petra [VerfasserIn] |
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| | Kapelle, Andreas [VerfasserIn] |
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| | Backhaus, Marina [VerfasserIn] |
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| | Blank, Norbert [VerfasserIn] |
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| | Henes, Joerg [VerfasserIn] |
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| | Osiek, Silke [VerfasserIn] |
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| | Knothe, Anna [VerfasserIn] |
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| | Hoese, Guido [VerfasserIn] |
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| | Brandt-Jürgens, Jan [VerfasserIn] |
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| | Maltzahn, Anja [VerfasserIn] |
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| | Specker, Christof [VerfasserIn] |
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| | Müller-Ladner, Ulf [VerfasserIn] |
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| | Schulze-Koops, Hendrik [VerfasserIn] |
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| Titel: | Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases |
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| Verf.angabe: | Rebecca Hasseli, Jutta G. Richter, Bimba Franziska Hoyer, Hanns-Martin Lorenz, Alexander Pfeil, Anne Constanze Regierer, Tim Schmeiser, Anja Strangfeld, Reinhard E. Voll, Andreas Krause, Sabine Reckert, Anett Gräßler, Petra Saar, Andreas Kapelle, Marina Backhaus, Norbert Blank, Joerg Henes, Silke Osiek, Anna Knothe, Guido Hoese, Jan Brandt-Jürgens, Anja Maltzahn, Christof Specker, Ulf Müller-Ladner, Hendrik Schulze-Koops, COVID-19 task force of the German Society of Rheumatology collaborators |
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| E-Jahr: | 2023 |
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| Jahr: | April 17, 2023 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 26.06.2023 |
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| Titel Quelle: | Enthalten in: RMD Open |
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| Ort Quelle: | London : BMJ Publishing Group, 2015 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 9(2023), 2 vom: Apr., Artikel-ID e002998, Seite 1-11 |
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| ISSN Quelle: | 2056-5933 |
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| Abstract: | Objective: To analyse the clinical profile of SARS-CoV-2 breakthrough infections in at least double-vaccinated patients with inflammatory rheumatic diseases (IRDs). - Methods: Data from the physician-reported German COVID-19-IRD registry collected between February 2021 and July 2022 were analysed. SARS-CoV-2 cases were stratified according to patients’ vaccination status as being not vaccinated, double-vaccinated or triple-vaccinated prior to SARS-CoV-2 infection and descriptively compared. Independent associations between demographic and disease features and outcome of breakthrough infections were estimated by multivariable logistic regression. - Results: In total, 2314 cases were included in the analysis (unvaccinated n=923, double-vaccinated n=551, triple-vaccinated n=803, quadruple-vaccinated n=37). SARS-CoV-2 infections occurred after a median of 151 (range 14-347) days in patients being double-vaccinated, and after 88 (range 14-270) days in those with a third vaccination. Hospitalisation was required in 15% of unvaccinated, 8% of double-vaccinated and 3% of triple-vaccinated/quadruple-vaccinated patients (p<0.001). Mortality was 2% in unvaccinated, 1.8% in the double-vaccinated and 0.6% in triple-vaccinated patients. Compared with unvaccinated patients, double-vaccinated (OR 0.43, 95% CI 0.29 to 0.62) and triple-vaccinated (OR 0.13, 95% CI 0.08 to 0.21) patients showed a significant lower risk of COVID-19-related hospitalisation. Using multivariable analysis, the third vaccination was significantly associated with a lower risk for COVID-19-related death (OR 0.26; 95% CI 0.01 to 0.73). - Conclusions: Our cross-sectional data of COVID-19 infections in patients with IRD showed a significant reduction of hospitalisation due to infection in double-vaccinated or triple-vaccinated patients compared with those without vaccination and even a significant reduction of COVID-19-related deaths in triple-vaccinated patients. These data strongly support the beneficial effect of COVID-19 vaccination in patients with IRD. - Trial registration number EuDRACT 2020-001958-21. |
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| DOI: | doi:10.1136/rmdopen-2023-002998 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1136/rmdopen-2023-002998 |
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| | Volltext: https://rmdopen.bmj.com/content/9/2/e002998 |
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| | DOI: https://doi.org/10.1136/rmdopen-2023-002998 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antirheumatic agents |
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| | COVID-19 |
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| | inflammation |
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| | vaccination |
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| K10plus-PPN: | 1850953406 |
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| Verknüpfungen: | → Zeitschrift |
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Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases / Hasseli, Rebecca [VerfasserIn]; April 17, 2023 (Online-Ressource)
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